紫杉烷二萜类化合物精细立体结构研究  

STUDIES ON THE FINE STEREOSTRUCTURE OF TAXOIDS

作　　者：吴楠[1] 吕扬[1] 郑启泰[1] 方唯硕[1] 高永莉 方起程[1] 周同惠[1] 

机构地区：[1]中国医学科学院

出　　处：《药学学报》1998年第10期759-763,共5页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金

摘　　要：抗肿瘤药物紫杉醇（ｔａｘｏｌ）是一类新型的纺锤体毒药物。已有的关于紫杉醇及其类似物的构效关系研究表明其分子结构中六元Ａ环的Ｃ１３侧链与Ｃ４Ｃ５Ｃ２０四元氧环对活性有重要贡献。本文研究了紫杉烷二萜类化合物中５／７／６三环骨架Ｃ４取代方式不同的化合物（４个）及６／８／６三环骨架Ｃ４取代方式不同的３类化合物（１０个）的晶体结构，阐述了晶态下紫杉烷二萜类化合物因Ｃ４取代方式不同对分子立体结构的影响，从晶体学角度给出６／８／６／４骨架与抗癌活性的关系。The anticancer drug taxol is a new type antimicrotubular drug. The structure activity relationship study on taxol and its analogs has indicated the importance of the C 13 side chain and the C 4 C 5 C 20 epoxypropane group. The crystal structures of 4 taxoids having the basic skeleton with 5/7/6 membered ring and three types of 10 taxoids having the basic skeleton with 6/8/6 membered ring have been analyzed. The effects of the induction by different substructures at C 4 on the stereostructures of taxoids were studied, and the relationship between the 6/8/6/4 skeleton and the anticancer activity was discussed from the crystallographic point.

关 键 词：紫杉烷二萜 晶体结构 构效关系 

分 类 号：R979.1[医药卫生—药品] R962[医药卫生—药学]