幽门螺杆菌、炎症、白介素—8与十二指肠溃疡的寒热辨证  

Differential Diagnosis of Cold - heat Syndrome in Duodena] Ulcer and Helicobacter Pylori - inflammation-interleukin-8

作　　者：张学智[1] 纪保安[2] 陈宝雯[2] 贾博琦[2] 谢竹藩[1] 

机构地区：[1]北京医科大学第一医院中西医结合研究所,北京西城区100034 [2]北京医科大学第一医院消化科

出　　处：《中医杂志》1998年第10期616-618,共3页Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(39570888)

摘　　要：选用48例十二指肠溃疡患者进行寒热辨证,根据辨证分寒证组、无明显寒热证组及热证组,并研究其与幽门螺杆菌(HP)、急慢性炎症程度、白细胞介素—8(IL—8)的相关性。结果显示:热证组HP感染及感染密度明显高于寒证组(P<0.001);急、慢性炎症程度在热证组较寒证组重;IL—8在热证组胃粘膜中明显高于寒证组及无明显寒热证组(P<0.05)。提示溃疡病寒热证型与HP感染、急慢性炎症程度明显相关。IL—8可能是寒热证形成的机制之一。Forty - eight cases of duodenal ulcer were differentially diagnosed for their syndrome types as heat type, cold type and non -heat-non-cold type, with their coincidence with helicobactor - pylori (HP), acute and chronic inflammatory degrees, IL -8. Results revealed that the incidence of HP infection and its severity were higher in the heat group than in the cold group. The IL - 8 in the stomach mucosa in the heat group was markedly higher than in the other groups (P<0. 05), demonstrating that the cold-heat types were closely related to the infection of Hp. while IL - 8 might be one of the molecular mechanisms in the formation of cold - heat syndrome types formation.

关 键 词：十二指肠溃疡 中医 诊断 幽门螺杆菌 炎症 

分 类 号：R259.731[医药卫生—中西医结合]