卡维地洛对轻、中度慢性心力衰竭患者左房容积指数及预后的影响  

Effect of carvedilol on left atrial volume index and prognosis in patients with mild to moderate heart failure

作　　者：廖凯[1] 杨成明[1] 曾春雨[1] 方玉强[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所心内科,重庆400042

出　　处：《重庆医学》2010年第2期168-170,共3页Chongqing medicine

摘　　要：目的探讨卡维地洛对左房容积指数(LAVi)及慢性心力衰竭(心衰)患者预后的影响。方法选择轻、中度慢性心衰患者53例,随机分为卡维地洛组25例与对照组28例。观察LAVi水平及预后,终点事件为心源性死亡、心衰再住院。结果(1)卡维地洛组第3个月、第6个月LAVi水平分别为(37±9.8)mL/m2(、33±13.7)mL/m2,较服药前(42±11.7)mL/m2降低(P<0.05),第6个月LAVi水平明显低于同期对照组(P<0.05);(2)随访(12±4)个月,卡维地洛组3例达到终点事件,对照组7例达到终点事件,卡维地洛组预后好于对照组(P<0.05)。结论在轻、中度慢性心衰患者中,卡维地洛加入标准治疗后可以降低LAVi水平,并改善患者预后。Objective To investigate the effect of carvedilol on left atrial volume index and prognostic in the patients with mild to moderate heart failure. Methods Fifty-three patients with mild to moderate chronic heart failure（CHF） were randomized to carvedilol group（n=25） and control group（n= 28）. Then to observe left atrial volume index（LAVi）and prognosis. The end point was cardiac death,hospitalisation for worsening heart failure. Results （1）The levels of LAVi at 3 month and 6 month in carvedilol group were（37±9.8）mL/m^2 and（33 ±13. 7）mL/m^2 respectively, significantly lower than before crvedilol treatment（42±11. 7） mL/m^2 （P〈0.05） ,the level of LAVi at 6 month significantly lower than concurrent control group（P〈0.05） ;（2） Over a mean follow-up period of（12±4）months,the end point was reached by 3 patients in carvedilol group and 7 patients in control group. The prognosis in carvedilol group was better than that in control group（P〈0.05）. Conclusion Carvedilol added to conventional treatment in the patients with mild to moderate heart failure could cause a decrease in LAVi and improve prognosis.

关 键 词：卡维地洛 慢性心力衰竭 左房容积指数 预后 

分 类 号：R541.61[医药卫生—心血管疾病] R972[医药卫生—内科学]