肾病综合征患者血清IL-4和IL-10水平的变化及意义  

Changes of serum levels of IL-4 and IL-10 in patients with nephrotic syndrome and its clinical significance

作　　者：范兴忠[1] 李宏[1] 刘文峰[2] 赵建强[1] 

机构地区：[1]山东省潍坊市人民医院肾内科,261041 [2]山东寿光潍坊医学院附属寿光医院,262700

出　　处：《免疫学杂志》2010年第1期56-57,62,共3页Immunological Journal

摘　　要：目的通过观察肾病综合征(NS)免疫治疗前后白细胞介素-4(interleukin-4,IL-4)和IL-10水平的变化,探讨其临床意义。方法以ELISA检测52例NS患者在接受强的松和环磷酰胺治疗前及4周后血清IL-4和IL-10水平。结果NS患者血清IL-4水平显著增高(P<0.01),并与血清β_2微球蛋白呈显著正相关(n=52,r=0.352.P<0.05),血清IL-10水平与健康人无显著差异。治疗4周后血清IL-4和IL-10水平显著降低(P<0.05),尿蛋白排出量显著低于治疗前(P<0.05)。结论IL-4、IL-10参与了NS发病过程,强的松和环磷酰胺可通过调节IL-4和IL-10产生而调节NS的免疫紊乱,NS的免疫治疗方案可根据细胞因子水平(包括抗炎细胞因子IL-4和IL-10)调整。To investigate the roles of interleukin-4（IL-4） and interleukin-10（IL-10）in pathogenesis of nephrotic syndrome（NS）and its clinical significance.Serum levels of IL-4 and IL-10 in 52 patients with NS were determined by ELISA at pre-treatment and 4 weeks after treatment with prednisone and cyclophosphamide.Serum level of IL-4 in NS patients was significant higher than those in healthy controls（P 0.01）,and there was a positive correlation between serum IL-4 level and serumβ_2-MG（n=52,r=0.352,P0.05）,while no significant difference of serum IL-10 levels was found between NS group and healthy controls.At 4 weeks after treated with prednisone and cyclophosphamide, the serum levels of IL-4 and IL-10 as well as the 24-hour urinary protein excretion were significant lower than those in pre-treated NS patients（P0.05）.The results imply that IL-4 and IL- 10 may take part in immune pathogenesis of NS,while prednisone and cyclophosphamide may have a significant inhibiting effect on the production of IL-4 and IL-10 in NS,thus the immunotherapy of NS may he adjusted according to the immune activity of disease（including anti-inflammatory immune-regulating cytokines IL-4 and IL-10）.

关 键 词：肾病综合征 强的松 环磷酰胺 IL-4 IL-10 

分 类 号：R692.3[医药卫生—泌尿科学] R446.6[医药卫生—外科学]