合蕊五味子中两个新的三萜内酯及其在生物合成途径中的意义(英文)  

Propinic Lactones A and B,Two New Triterpenoids from Schisandra propinqua var. propinqua and the Significance in Biosythesis Pathway

作　　者：雷春[1] 普建新[1] 肖伟烈[1] 杨黎彬[1] 刘靖平[1] 陈纪军[1] 孙汉董[1] 

机构地区：[1]中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室,昆明650204

出　　处：《中国天然药物》2010年第1期1-5,共5页

基　　金：supported by the National Natural Science Foundation (No.30830115 and 20802082);the Major State Basic Research Development Program of China (No.2009CB522300 and 2009CB940900)~~

摘　　要：目的:研究合蕊五味子(Schisandra propinqua var. propinqua)地上部分化学成分。方法:利用正反相硅胶、高效液相色谱等现代分离技术进行分离,利用IR,UV,MS和NMR等现代波谱技术手段鉴定了它们的结构。结果:分离得到两个分别具有3,4-seco-cycloartane和3,4:9,10-secocycloartane型骨架的新三萜内酯:propinic lactones A(1)和B(2);同时分离得到了一个典型的cycloartane骨架三萜类化合物。结论:这两个新化合物在生源合成途径上具有重要意义,它们可能是连接cycloartane骨架三萜和schisandra降三萜骨架的重要中间体。AIM： To study the chemical constituents of the aerial parts of Schisandra propinqua var. propinqua. METHOD： Silica gel, C18 reversed phase silica gel and HPLC were used. The structures were elucidated by extensive spectroscopic methods. RESULT： Two new triterpenoids, propinic lactone A （1） with 3, 4-seco-cycloartane skeleton, and propinic lactone B （2） possessing 3, 4：9,10seco-cycloartane skeleton, together with a known typical cycloartane triterpenoid, schizandronic acid （3）, have been isolated and identified. CONCLUSION： These two new triterpenoids serve as two important bridge intermediates from cycloartane triterpenoids to Schisandra nortriterpenoids biogenetically.

关 键 词：五味子科 五味子属 合蕊五味子 三萜类化合物 

分 类 号：R284.1[医药卫生—中药学]