固公果根中的三萜类成分(英文)  

Triterpenoids from the Roots of Rose odorata var.gigantean

作　　者：刘岱琳[1,2] 朱珊[2] 马荣[3] 张静泽[1] 李赫宇[2] 陈红[1] 

机构地区：[1]中国人民武装警察部队医学院生药教研室,天津市职业与危害生物标志物重点实验室,天津300162 [2]天津尖峰天然产物研究开发有限公司,天津300457 [3]沈阳药科大学中药学院,沈阳110016

出　　处：《中国天然药物》2010年第1期12-15,共4页

基　　金：supported by the Doctoral Operation Foundation of Medical College of Chinese People's Armed Police Forces (No.WBS200804)~~

摘　　要：目的:研究固公果(Rose odorata Sweet var. gigantea(Coll.et Hemsl.)Rehd.et Wils)根中三萜类成分。方法:通过利用硅胶柱色谱、ODS柱色谱等色谱学分离,利用理化性质、现代波谱学以及化学沟通手段鉴定结构。结果:从固公果根乙酸乙酯层分离到9个三萜化合物,分别鉴定为白桦酸(1)、2α,3β,19β-trihydroxyurs-12-en-28-oic acid(2)、野鸦春酸(3)、2α,3α,19α,23-tetrahydroxyurs-12-en-28-oicacid(4)、2α,3β,19α-trihydroxyurs-12-en-28-oicacid(5)、kaji-ichigoside F1(6)、野蔷薇苷(7)、2α,3α,19α,23-tetrahydroxy-urs-12-en-28-oicacid-3-O-β-D-glucopyranosyl ester(8)、冬青苷B(9)。结论:化合物9为首次从蔷薇属植物中分离得到,化合物1-8为首次从该种植物中分离得到。AIM： To study the chemical constituents of the roots of Rose odorata Sweet var. gigantea （Coll. et Hemsl.） Rehd.et Wils. METHODS： Compounds were separated by column chromatography with silica gel, Sephadex LH-20 and ODS. Their structures were elucidated on the basis of physiochemical and spectral analyses. RESULTS： Nine compounds were isolated from the roots of R. odorata var. gigantea and their structures were identified as betulinic acid （1）, 2a, 3β, 19β-trihydroxyurs-12-en-28-oic acid （2）, euscaphic acid （3）, 2a, 3a, 19a, 23-tetrahydroxyurs- 12-en-28-oic acid （4）, 2a, 3fl, 19a-trihydroxyurs -12-en-28-oic acid （5）, kaji-ichigoside F1 （6）, rosamultin （7）, 2a, 3a, 19a, 23-tetrahydroxy-urs-12-en-28-oic acid-3-O-β-D-glucopyranosyl ester （8）, and Ilexoside B （9）. CONCLUSION： Compound 9 was isolated from the genus for the first time and compounds 1-8 were isolated from this plant for the first time.

关 键 词：固公果 三萜 蔷薇属 

分 类 号：R284.1[医药卫生—中药学]