秃瓣杜英茎叶化学成分(英文)  

Chemical Constituents from the Stems and Leaves of Elaeocarpus glabripetalus

作　　者：张盛[1] 陶正明[2] 张毅[3] 沈征武[1] 秦国伟[3] 

机构地区：[1]上海中医药大学中药学院,上海201023 [2]浙江省亚热带作物研究所,温州325028 [3]中国科学院上海药物研究所,上海201203

出　　处：《中国天然药物》2010年第1期21-24,共4页

基　　金：supported by Science and Technology Commission of Shanghai Municipality (No.06DZ22028)~~

摘　　要：目的:研究秃瓣杜英Elaeocarpus glabripetalus Merr.茎叶的化学成分。方法:采用硅胶柱色谱、Sephadex LH-20柱色谱、ODS反相柱色谱等方法对秃瓣杜英茎叶95%乙醇提取物进行分离和纯化,应用理化性质及波谱方法对实验得到的单体化合物进行结构鉴定。结果:分离并鉴定11个化合物,分别为:山柰酚(1)、β-谷甾醇(2)、葫芦素D(3)、没食子酸甲酯(4)、没食子酸乙酯(5)、槲皮素(6)、3,4-二羟基苯甲酸(7)、Mogroside I E1(8)、5R,6R-Epoxymogroside I E1(9)、山奈酚-7-O-α-L-吡喃阿拉伯糖苷(10)、芦丁(11)。结论:化合物2和3为首次从该植物中分离得到,其余9个化合物均为首次从杜英属植物中分得,对化合物8的结构首次进行了X-衍射分析。化合物9在体外实验中能增加脂肪细胞分泌脂联素的水平(25μg.mL-1浓度时增加1.32倍)。AIM： To investigate the chemical constituents of Elaeocatpus glabripetalus Merr.. METHODS： The compounds were isolated and purified by repeated column chromatography and their structures were identified by physicochemical and spectral methods, respectively. RESULTS： Eleven compounds were isolated from the stems and leaves of this plant, and identified as kaempferol （1）, β-sitosterol （2）, cucurbitacin D （3）, methyl gallate （4）, ethyl gallate （5）, quercetin （6）, 3,4-dihydroxybenzoic acid （7）, mogroside I E1 （8）, 5R, 6R-epoxymogroside I E1 （9）, kaempferol -7-O-α-L-arabinopyranoside （10） and rutin （11）. CONCLUSION： Compounds 2 and 3 were isolated from this plant for the first time and the other nine compounds were isolated from the genus of Elaeocarpus for the first time. Structure of compound 8 was firstly confirmed by X-ray analysis. Compound 9 can modestly increase adiponectin production （1.32 fold at 25μg.mL-1 in adipocytes.

关 键 词：秃瓣杜英 杜英属 葫芦素 

分 类 号：R284.1[医药卫生—中药学]