分子蒸馏技术分离厚朴油化学成分的GC-MS分析(英文)  

GC-MS Analysis of Cortex Magnolia Officinalis Oil Separated by Molecular Distillation

作　　者：袁雨婕[1,2] 余少冲[1,2] 葛发欢[1,2] 刘华 禤耀明 

机构地区：[1]中药提取分离过程现代化国家工程研究中心,广州510240 [2]中山大学,广州510275 [3]广州汉维机电有限公司,广州510500

出　　处：《中国天然药物》2010年第1期47-50,共4页

基　　金：supported by Key Projects in the National Science & Technology Pillar Program during the Eleventh Five-year Plan Period,"Research on Modern Extraction and Separation of TCM (No.2006BAI06A04)"~~

摘　　要：目的:以超临界CO2萃取厚朴酚的副产物──厚朴油为原料,研究了分子蒸馏技术分离厚朴油的分离效果。方法:保持刮膜式分子蒸馏仪温度140℃,真空度4Pa,对厚朴油进行蒸馏。采用GC-MS法分析蒸馏产物成分,采用HPLC法对蒸馏产物中厚朴酚、和厚朴酚定量。结果:分子蒸馏的轻组分鉴定出27种成分,主要是石竹烯氧化物、香木兰烯氧化物等挥发性成分;分子蒸馏的重组分鉴定出7种成分;厚朴油共鉴定出28种成分。其中α-毕澄茄烯、β-人参烯、α-依兰油烯、τ-依兰醇、香木兰烯氧化物这5种成分为首次从厚朴中鉴定。结论:分子蒸馏技术可用于分离厚朴油中挥发性成分,对厚朴油中厚朴酚与和厚朴酚具有蒸馏及富集效果。AIM： The effect of the Cortex Magnolia officinalis oil separated by molecular distillation （MD） was analyzed by GC-MS and HPLC. METHODS： The distillation process was performed under a temperature of 140 ℃, and a vacuum degree of 4 Pa. RESULTS： 27 chemical compounds were identified in the lighter component, which mainly were volatile components such as caryophyllene oxide, aromadendrene oxide etc. 7 chemical compounds were identified in the heavy component and 28 kinds of substances were identified in the crude Cortex Magnolia officinalis Oil. Among those substances, aromadendrene, α-bergamotene, α-muurolene, t-muurolol and aromadendrene oxide were authenticated for the first time from Cortex Magnolia officinalis. CONCLUSION： It was proved that MD technology can be applied to separate the volatile parts, condense magnolol and honokiol of Cortex Magnolia officinalis oil.

关 键 词：分子蒸馏 厚朴油 GC-MS HPLC 

分 类 号：R917[医药卫生—药物分析学]