通脉液对冠状动脉粥样硬化性心脏病患者血清ET、IL-18、M-CSF的影响  

Effect of Tongmai Liquid on ET,IL-18 and M-CSF in patients with coronary heart disease

作　　者：张大创[1] 罗陆一[1] 殷建明[1] 张卫斌[1,2] 黄梦雨[1,2] 赵珊珊[1,2] 

机构地区：[1]广东省深圳市中医院心血管科,广东深圳518033 [2]广州中医药大学

出　　处：《中成药》2010年第1期16-18,共3页Chinese Traditional Patent Medicine

摘　　要：目的:观察通脉液(黄芪、当归、川芎、丹参、地龙、石菖蒲、郁金和炒元胡)对冠状动脉粥样硬化性心脏病(CHD)患者血清内皮素(ET)、白细胞介素-18(IL-18)、巨噬细胞集落刺激因子(M-CSF)的影响。方法:将80例CHD心脾气虚兼痰瘀气滞证患者随机分为两组,治疗组40例,口服通脉液30mL,3次/d,疗程30d;对照组40例,口服麝香保心丸,2粒/次,3次/d,疗程30d。治疗前后采集空腹静脉血,测定血清ET、IL-18、M-CSF水平。结果:两组治疗后血清ET、IL-18、M-CSF水平显著降低(P<0.05),两组治疗后血清ET水平比较,有显著差异(P<0.05),血清IL-18、M-CSF水平比较,无显著差异(P>0.05)。结论:通脉液能降低CHD患者ET、IL-18、M-CSF水平,且无任何毒副作用。AIM ： To observe the effect of Tongmai Liquid on endothelin（ET） , interlenkin-18 （IL-18） , macrophage colony stimulating factor （M-CSF） in patients with coronary heart disease （CHD）. METHODS： Eighty patients with coronary heart disease accompanied by heart and spleen qi deficiency and qi stagnanty ＋ phlegm stasis and were randomly assigned into test group and control groups. Forty patients in test group were treated with Tongmai Liquid, 30 mL, thrice per day, Forty patients in control group were treated with Shexiang Baoxin Pills, 2 pills every time, thrice per day. The therapeutic course for both groups was 30 days. The blood-serum ET, IL-18 and M-CSF had been tested before and after the treatment. RESULTS： The levels of blood-serum ET,IL-18 and MCSF in the two groups decreased significantly after treatment （ P 〈 0.05 ）. There＇ s significant difference in two groups＇ blood-serum of ET（P 〈0.05） , There＇ re no significant diffference in two groups＇ blood-serum level IL-18 and of M-CSF （P 〉 0.05 ）. CONCLUSION： Tongmai Liquid may decrease blood-serum level of ET, IL-18 and M-CSF in patients with coronary heart disease without side effect.

关 键 词：通脉液 CHD ET IL-18 M—CSF 

分 类 号：R287[医药卫生—中药学]