止痛活血压敏胶贴片中有效成分的体外释放研究  

An investigation on the in vitro release behavior of TCM components in different pressure sensitive adhesives

作　　者：常明明[1] 孙玉明[1] 汪晴[1] 钱勇 张欣[1] 王天富[1] 

机构地区：[1]大连理工大学制药工程,辽宁大连116012 [2]福尔波胶粘剂上海有限公司,上海201613

出　　处：《中成药》2010年第1期43-47,共5页Chinese Traditional Patent Medicine

基　　金：国家十一五科技支撑计划项目(2006BAI09B08-12)

摘　　要：目的:以丙烯酸酯和热熔胶为基质制备止痛活血(延胡索、川乌、白芍、三七等)压敏胶贴片来考察不同压敏胶基质对中药有效成分体外释放率的影响。方法:采用Permcell扩散池进行体外释放实验,用HPLC测定不同类型基质对止痛活血类中药中延胡索乙素、乌头碱、芍药苷、人参皂苷Rg1等4种有效成分在接收液中累积浓度变化。结果:丙烯酸酯压敏胶(含羧基官能团)对生物碱类成分释放的影响较大,KT-A型热熔胶中有效成分释放速率与分子量呈一定相关性,2501s型热熔胶贴片中4种成分的12h累积释放率比较均衡(30%～43%)。结论:有效成分的分子量越小释放速率越快,压敏胶的类型和组成明显影响中药有效成分的体外释放行为。AIM： To examine the effect of acrylic ester and thermosol respectively as pressure sensitive adhesive matrix of zhitong huoxue extract （ Rhizoma Corydalis, Radix aconiti,Radix Paeoniae alba, Radix et notoginseng ginseng,etc） on the dissolution of effective constituent from zhitong huoxue extract. METHODS： The in vitro release experiment was carried out on Permcell diffusion cell, HPLC method was applied to determining the cumulative elease rate of tetrahydropalmatine, aconitine, paeoniflorin and ginsenoside Rgl from zhitong huoxue pressure sensitive adhensive. RESULTS： The acrylic ester matrix had sound controlled release profile in vitro of alkaloid components. In KT-A thermosol matrix, the in vitro release rate proved to be inversely proportional to the molecular weight （R = 0.91 ） of the effective constituents, while the 2501 s matrix presented a steadily cumulative release rate over 12 h （30% -43% ）. CONCLUSION： Good release rates are observed with effective constituent with small molecular weight, adhesive composition of matrix has an obvious effect on the in vitro release behavior of zhitong huoxue extract.

关 键 词：丙烯酸酯 热熔胶 体外释放 止痛活血膏 延胡索乙素 乌头碱 芍药苷 人参皂苷RG1 

分 类 号：R944[医药卫生—药剂学]