肝素和低效价肝素对兔动脉壁微量元素的影响  

Effects of Heparin and Low Titer Heparin on Trace Elements in Rabbit Arterial Wall

作　　者：王菊英[1] 夏洪印[2] 马剑峰[1] 魏欣冰[1] 李心河[2] 

机构地区：[1]山东医科大学基础医学院药理教研室,济南250012 [2]山东医科大学附属医院中心实验室

出　　处：《广东微量元素科学》1998年第10期11-14,共4页Trace Elements Science

摘　　要：给家兔静脉注射不同效价肝素,并用原子发射光谱仪(DCP-AES)测定兔动脉壁中 Mo、Zn、Se、Mn、Al、Cd、Fe、Mg、Ca、Pb、Cu、Ni、Ti、Co、K、Na、Li、Cr 元素含量。结果表明,与盐水组比较,商品肝素、低效价肝素(38u/mg)使 Mg、K 明显升高(P<0.05或 P<0.01);低效价肝素使 Zn 显著升高(P<0.05);而商品肝素使 Co 显著升高,Al 显著降低(P<0.05);两组肝素均使 Mg/Ca、Cu/Zn、K/Na 比值明显升高(P<0.05或 P<0.01)。The content of Mo,Zn,Se,Mn,Al,Cd,Fe,Mg,Ca,Pb,Cu,Ni,Ti,Co,K, Na,Li,Cr in rabbit arterial wall was determined with DCP atomic emission spectrometer(DCP-AES) after the rabbits were introveneously injected different titer heparins. The results showed that the content of Mg,K in rabbits of commodity heparin and low titer heparin(38 u/mg)groups significantly increased compared with that of normal saline group(P<0.05 or P<0.01). At the same time,the content of Zn of low titer heparin group remarkably increased(P<0.05),and in the commodity heparin group,the content of Co notably increased while the content of Al decreased(P<0.05). The ratios of Mg/Ca,Cu/ Zn,K/Na of both groups were obviously increased(P<0.05 or P<0.01).

关 键 词：肝素 微量元素 动脉壁 生物制剂 

分 类 号：R973.2[医药卫生—药品]