大黄中蒽醌类成分清除氧自由基作用的研究  

ESR Study on the scavenging effects of the free anthraquinones from Rheum palmatum L. on superoxide anion radical

作　　者：罗志毅 黄新[2] 包国荣[3] 

机构地区：[1]漳州片仔癀药业股份有限公司,漳州363000 [2]中国科学院福建物质结构研究所,福州350001 [3]福建中医学院药学系,福州350003

出　　处：《海峡药学》2009年第12期43-45,共3页Strait Pharmaceutical Journal

摘　　要：目的通过研究大黄中游离蒽醌类成分大黄酸、芦荟大黄素、大黄素、大黄素甲醚和大黄酚清除超氧阴离子自由基(O2.)的作用,从分子生物学的角度探讨大黄延缓衰老作用的可能机理。方法采用电子自旋共振技术(ESR)分别检测大黄中游离蒽醌类成分对O2.的清除作用。结果大黄中游离蒽醌类成分对O2.的清除作用,依次为大黄酸>大黄酚>大黄素>大黄素甲醚>芦荟大黄素。结论大黄所具有的延缓衰老的作用,可能与其所含的游离蒽醌类成分大黄酸、芦荟大黄素、大黄素、大黄素甲醚和大黄酚具有清除O2.的能力有关。OBJECTIVE To study the scavenging effects of Rhein, Aloe-emodin, Emodin, Physcion and Chrysophanol which were the free anthraquinones from Rheum palmatum L. on superoxide anion radical and to inverstigate the mechanism of Rheum palmatum L. in retarding aging at molecular biology level. METHODS The electron spin resonance （ESR） was used to observe the scavenging effects on the superoxide anion radical （O2^-） of the free anthraquinones from Rheum palmatum L. RESULTS All of the Rhein, Aloe-emodin, Emodin, Physcion and Chrysophanol were effective inscavenging Of produced in the alkaline DMSO system, and the ability was Rhein〉Chrysophanol 〉 Emodin 〉 Physcion 〉 Aloe-emodin. CONCLUSION Rheum palmatum L. has the effect of retarding aging. Perhaps this is relevant to the scavenging effects on the superoxide anion radical （O2^-） of the free anthraquinones from the herb.

关 键 词：大黄/药理学 抗氧化剂/药理学 自由基清除剂/药理学 衰老/药物作用 电子自旋共振(ESR)/方法 

分 类 号：R969.4[医药卫生—药理学] R969[医药卫生—药学]