灯盏花素脂质体前体与灯盏花素片抗脑缺血再灌注损伤药效学比较研究  

Comparison of pharmacodynamic effect between breviscapine proliposome and breviscapine tablet against cerebral ischemia-reperfusion injury in rats

作　　者：黄粮[1] 张洪艳[1] 刘金荣[1] 翟凤国[1] 章新华[1] 王怀良[1] 

机构地区：[1]中国医科大学药学院临床药理教研室,辽宁沈阳110001

出　　处：《解剖科学进展》2010年第1期9-11,共3页Progress of Anatomical Sciences

基　　金：辽宁省教育厅科学技术研究项目No.05L516)

摘　　要：目的比较灯盏花素脂质体前体(breviscapine proliposome,PS)与灯盏花素片(breviscapine tablet,Bre T)抗脑缺血-再灌注(ischemia-reperfusion,IR)损伤药效学作用。方法线栓法制作大鼠大脑中动脉缺血-再灌注脑损伤模型,经2,3,5-氯化三苯基四氮唑(TTC)染色,检测大鼠脑梗死面积;毛细玻管法检测小鼠凝血时间(coagulation time,CT)。结果与Bre T组比较,PS低、高剂量均减少脑缺血-再灌注引起的脑组织梗死面积,且有剂量依赖性(P<0.05)。PS低、高剂量组比Bre T组显著延长小鼠凝血时间,且有剂量依赖性(P<0.01)。结论灯盏花素脂质体前体减少大鼠脑组织梗死面积百分比、延长小鼠凝血时间,其药效学作用明显优于灯盏花素片。Objective To compare the protective effect of breviscapine proliposome（PS） and breviscapine tablet（Bre T） against cerebral ischemia-reperfusion injury（IR）.Methods Intraluminal filament technique was used to make cerebral ischemia-reperfusion injury model in rats.The cerebral infarct area was measured by TTC-staining,and clotting time was determined by capillary method.Results Compared with Bre T,PS decreased cerebral ischemiareperfusion infarct area in a dose dependent manner（p〈 0.05）.Compared with Bre T,PS prolonged coagulation time dose dependently in IR mice（p〈 0.01） .Conclusion PS produced more effective effects than Bre T in amelioration of middle cerebral artery occlusion induced cerebral ischemia-reperfusion injury.

关 键 词：灯盏花素 脂质体前体 脑缺血-再灌注损伤 大鼠 

分 类 号：R965[医药卫生—药理学]