氟西汀抑制野百合碱诱导的大鼠右心室肥厚及GATA结合蛋白4的表达  

Involvement of GATA-4 in fluoxetine-produced inhibition on right ventricular hypertrophy by monocrotaline in rats

作　　者：王寒明[1] 高杰[2] 章新华[1] 王怀良[1] 

机构地区：[1]中国医科大学药学院临床药理教研室,辽宁沈阳110001 [2]中国医科大学基础医学院解剖教研室,辽宁沈阳110001

出　　处：《解剖科学进展》2010年第1期58-61,共4页Progress of Anatomical Sciences

基　　金：国家自然科学基金(No.30271510;No.30572194);辽宁省教育厅高等学校科学研究项目(No.06L516)

摘　　要：目的研究氟西汀(Fluoxetine,Flu)抑制野百合碱(Monocrotaline,MCT)诱导的大鼠右心室肥厚与(GATA binding protein 4)结合蛋白4(GATA-4)表达的关系。方法建立MCT诱导的慢性肺动脉高压大鼠模型。灌胃给予大鼠不同剂量的Flu,检测右心室肥厚指标和心室GATA-4蛋白表达水平。结果MCT诱导的大鼠右心指数及右心室GATA-4蛋白表达均比正常对照组显著增加,Flu剂量依赖地抑制了右心指数及右心室GATA-4表达增加,而各组间左心室和室间隔的GATA-4表达没有明显变化。结论选择性5-羟色胺再摄取抑制剂Flu抑制MCT诱导的大鼠右心室肥厚可能与抑制GATA-4表达有关。Objective To study the involvement of GATA bing protein 4（GATA-4） in fluoxetine-produced inhibition on right ventricular hypertrophy induced by monocrotaline（MCT） in rats.Methods MCT-induced pulmonary arterial hypertension in rats was established.Rats were treated with different doses of fluoxetine by gavages.The variables of right ventricular hypertrophy and GATA-4 expression in ventricle were measured.Results MCT caused right ventricular hypertrophy and increased expression of GATA-4 in the right,rather than in the left heart.Fluoxetine inhibited the increase of both right ventricular index and GATA-4 expression in right ventricle dose dependently.Conclusion Fluoxetine inhibited MCT-induced right ventricular hypertrophy in rats,in which the potential role of GATA-4 might be involved.

关 键 词：野百合碱 氟西汀 结合蛋白4 5-羟色胺 右心室肥厚 大鼠 

分 类 号：R965[医药卫生—药理学]