快中子对X和γ射线诱发淋巴细胞微核效应的比较研究  

A comparative study on micronuclei induced by fast neutrons versus X and 60~Co γ rays in human peripheral blood lymphocytes.\

作　　者：白玉书[1] 黄绮龙[1] 关树荣 马剑锋 

机构地区：[1]卫生部工业卫生实验所

出　　处：《中华放射医学与防护杂志》1998年第4期259-262,共4页Chinese Journal of Radiological Medicine and Protection

基　　金：卫生部科学研究基金

摘　　要：目的比较２．１４ＭｅＶ中子对１８０ｋＶＸ射线和６０Ｃｏγ射线诱发微核的效应。方法用不同剂量快中子、Ｘ射线和γ射线照射离体人血，观察双核淋巴细胞微核，求出快中子对Ｘ和γ射线的相对生物效能。结果２．１４ＭｅＶ中子对１８０ｋＶＸ射线和６０Ｃｏγ射线的相对生物效能在１～３Ｇｙ范围内，随剂量增加而降低，平均分别为３．８８和４．５０。结论２．bjective\ To compare the effectiveness of 2.14MeV neutrons versus 180kV X- rays and 60~Co γ rays in producing micronuclei in human lymphocytes.Methods\ Heparinized whole blood samples were exposed to fast neutrons,X rays and 60~Co γ rays,respectively.Micronuclei in binuclear lymphocytes(CB method)were scored.Relative biological effectiveness (RBE) values were derived.Results\ RBE values of 2.14MeV neutrons ranging from 1 to 3 Gy decreased with increasing dose.They averaged 3.88(D x/D n) and 4.50(Dγ/Dn),respectively.Conclusion\ 2.14MeV neutrons have higher biological effectiveness in inducing micronuclei.

关 键 词：快中子 X射线 ^60CO Γ射线 淋巴细胞 微核效应 

分 类 号：R144.1[医药卫生—公共卫生与预防医学] Q691.4[生物学—生物物理学]