蜂花粉对γ射线受照大鼠骨髓造血组织影响的病理学研究  

Morphometric changes in epithelial cell nuclei of rat thyroid follicles induced by 131I and 132I.\

作　　者：曹幼甫[1] 蒋滢[1] 毛棣华[1] 顾永平[1] 黄美英[1] 殷伟平[1] 

机构地区：[1]苏州医学院病理教研室

出　　处：《中华放射医学与防护杂志》1998年第4期269-270,共2页Chinese Journal of Radiological Medicine and Protection

摘　　要：蜂花粉对γ射线受照大鼠骨髓造血组织影响的病理学研究曹幼甫蒋滢毛棣华顾永平黄美英殷伟平辐射损伤不仅见于核战争或核事故，也见于核能的临床医学的应用，从而促使人们开展抗辐射效应药物的研究，国内在中草药方面进行了探索［１］。蜂花粉作为一种天然营养保健品，对辐...Objective\ To study harmfulness of radioiodine and its medical protection.Method\ By using image analysis technique and morphometry,changes in morphometric parameters in epithelial cell nuclei of rat thyroid follicles were determined 20 months after injection of 131I and 132I.Results\ The results showed that in various dosage groups the area and eqivalent diameter enlarged,the morphometric factor was evidently smaller than that of the control group(P<0.05 or P<0.01),and the form irregular index was significantly larger than that of the control group (P<0.05 P<0.01).The volume density, surface area density,numerical density of nuclei of follicular epithelial cells in various dose groups all showed the feature of increase at first and reduction afterwards.Conclusion\ It is indicated that the nuclei of epithelial cells increased and its shape became not only flat,but also anisomorphic after the cells were irradiated with radioiodine.The reason why volume density and surface area density showed increase or decrease is due to the change in numerical density of nuclei of epithelial cells.It was found by regresion analysis of the numerical density of nuclei of epithelial cells and incidence of thyroid tumor induced by radioiodine that they bear a remarkable positive correlation[Y=1/(3.37×10-3+5.85×103/X 1),R1=0.8435],suggesting that the incidence of thyroid tumor is related to the number of cell per unit volume.

关 键 词：蜂花粉 Γ射线 骨髓造血组织 放射损伤 

分 类 号：R818.83[医药卫生—放射医学] R285.5[医药卫生—临床医学]