慢性乙型肝炎合并巨细胞病毒感染93例分析  

Cytomegalovirus Co-infection in Patients with Chronic Hepatitis B: Analysis of 93 Cases

作　　者：周东辉[1] 刘雁雁[1] 唐保元[1] 贾辅忠[1] 

机构地区：[1]南京医科大学第一附属医院传染科

出　　处：《南京医科大学学报（自然科学版）》1998年第5期399-401,共3页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：为探讨慢性乙型肝炎合并巨细胞病毒（ＣＭＶ）感染对肝功能、ＨＢＶ复制的影响，对９３例慢性乙肝分别检测了抗－ＣＭＶＩｇＭ、ＨＢＶＤＮＡ及生化指标；另２０例健康人检测抗－ＣＭＶＩｇＭ作对照。结果显示，慢性乙肝病例中抗－ＣＭＶＩｇＭ阳性率为１８．３％，阳性病例的生化指标ＧＧＴ、ＴＢｉｌｉ高于阴性者，尤其在慢性重度肝炎和肝炎肝硬变病例中（Ｐ＜０．０５）。且阳性病例中ＨＢＶＤＮＡ阳性率亦高于阴性者（Ｐ＞０．０５）。结果提示，ＣＭＶ感染好发于免疫虚损的宿主，又可抑制宿主免疫功能，有利于ＨＢＶ复制。To investigate the effect of cytomegalovirus(CMV) co-infection on fluctuation of liver function and HBV replication in patients with chronic hepatitis B(CHB), sera from 93 cases with CHB were detected for CMV IgM antibodies、 HBV DNA and biochemical parameters. Control sera taken from twenty normal persons were tested for CMV IgM antibodies. Frequency of CMV IgM antibodies in patients with CHB was 18.3%. Levels of total bilibrubin and gammaglutamyltranspeptidase (GGT) in CMV seropositive cases were higher than those in CMV seronegative ones, especially in severe chronic hepatitis and HLC (hepatitis & liver cirrhosis) ones (P<0.05). Positive rate of HBV DNA in CMV seropositive cases was higher than that in CMV seronegative ones(P>0.05). The results suggested that CMV infection be predisposed in the immunocompromised host, and depress the host′s immune function as well, which favour replication of HBV. The patients′ liver dysfunction was deteriorated by CMV co-infection.

关 键 词：巨细胞病毒 免疫功能 乙型肝炎 

分 类 号：R512.620.6[医药卫生—内科学] R512.99[医药卫生—临床医学]