白细胞功能多极化及其意义  

Functional Multi-polarization of White Blood Cells and Its Significance——Editorial

作　　者：吴克复[1] 马小彤[1] 

机构地区：[1]中N医学科学院、北京协和医学院血液学研究所、血液病医院实验血液学国家重点实验室,天津300020

出　　处：《中国实验血液学杂志》2010年第1期1-6,共6页Journal of Experimental Hematology

基　　金：国家自然基金(编号30872983,30672364);天津市应用基础重点项目(编号07JCZDJC07600)

摘　　要：免疫与造血是实验血液学的基本课题之一。免疫功能是白细胞的主要功能,免疫反应的多样性和复杂性令人困惑。30年前发现的免疫细胞的功能性极化促进了对淋巴细胞分化的研究,近年来对淋巴细胞、单核/巨噬细胞功能多极化的研究为阐明免疫细胞的调控网络奠定了基础,为阐明免疫反应的多样性和复杂性提供了线索,也为深入研究造血细胞的分化拓展了思路。本文对淋巴细胞、单核/巨噬细胞和树突细胞的多极化及其作用和意义,尤其是在细胞因子风暴和白血病、肿瘤的前炎症状态发生中的可能作用进行评述。Immune and hemopoiesis are one of basic project of experimental hematology. Immune function is a essential activity of white blood cells. It was puzzled for the diversity and complexity of immune response. Polarized immune response of immune cells was discovered 30 years ago, which facilitates the study on differentiation of lymphocyte. Recently recognition on multifunctional polarized immune response of lymphocyte and monocyte/ macrophage would promote to elucidate the regulatory network of immune cells, diversity and complexity of immune response as well as the study on hemopoiesis. In this paper the approach of multifunctional polarized immune response of lymphocyte, monocyte/macrophage and dendritic cells were reviewed, and their role, especially in cytokine storm and tumor pro-inflammation condition were discussed.

关 键 词：淋巴细胞亚群 巨噬细胞亚群 树突细胞亚群 免疫极化 

分 类 号：R318.04[医药卫生—生物医学工程]