小细胞肺癌并发抗利尿激素分泌不当综合征临床特点的回顾性研究  

THE RETROSPECTIVE STUDY OF SYNDROME OF INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION(SIADH)IN PATIENTS WITH SMALL-CELL LUNG CANCER

作　　者：高俊珍[1] 付秀华[1] 李国华[1] 王立红[1] 成忠红[1] 所鸿[1] 

机构地区：[1]内蒙古医学院附属医院呼吸内科,内蒙古呼和浩特010050

出　　处：《内蒙古医学院学报》2009年第6期525-527,536,共4页Acta Academiae Medicinae Neimongol

基　　金：内蒙古医学院附属医院重大课题(NYFYZD2006005)

摘　　要：目的：分析探讨合并抗利尿激素分泌不当综合征（SIADH）的小细胞肺癌（SCLC）病人的临床特点。方法：回顾性分析我院1998～2D08年合并SIADH的16例SCLC病人的临床资料，并与85例正常血钠的SCLC病人进行对比。结果：SCLC合并SIADH的发生率为5．97％（16／268）；两组病人在初始发病症状和血钠值方面存在显著差异，SIADH组出现胸腔积液和多部位转移的比例要多于正常血钠组，差异显著。正常血钠组的1a生存率是31．76％，而SIADH组是18．75％，但无统计学差异。结论：SIADH提示SCLC的潜在可能，应该仔细筛查恶性肿瘤；并发SIADH的SCLC具有更差的预后。Objective： This study was performed to investigate the prognostic value of inappropriate antidiuretic hormone secretion （SIADH） in small cell lung cancer （SCLC）. Methods： Data was obtained from a total of 268 cases of patients diagnosed with small cell lung cancer （SCLC） from 1998 to 2008.16 of 101 patients showed SIADH and the remaindering 85 showed normal serum sodium value. We retrospectively investigated the clinical charaterize of these patients. Results： cases of SCLC patients （5.97%） had SIADH. In the group with SIADH and the group with normal serum sodium, 1 - year survival rates were 18.75% and 31.76% respectively, but there is no statistics significance. Two groups of patients have the significance difference in the initial symptom and the serum sodium value （P 〈 0.05）. Patients with SIADH have more chance to present the Pleural effusion and the multiple metastasis than the patients with normal serum sodium （ P 〈 0.05 ）. Conclusions： The SIADH appearanee suggests the existence of SCLC, so should be meticulously scrutinized for a possible malignancy. SIADH is a poor prognostic factor for SCLC.

关 键 词：小细胞肺癌 抗利尿激素分泌不当综合征 

分 类 号：R563.9[医药卫生—呼吸系统]