催醒宁氨茶碱胃复安或美解眠全麻催醒时对人血浆β-内啡肽的影响  

The Effects of 705, Aminophyline, Metoclopramide or Megimidum on Plasma β Endorphine during Awakening General Anesthesia

作　　者：朱阿立[1] 徐振邦[1] 

机构地区：[1]上海华山医院麻醉科

出　　处：《临床麻醉学杂志》1998年第4期223-224,共2页Journal of Clinical Anesthesiology

摘　　要：目的：观察使用催醒宁、氨茶碱、胃复安或美解眠催醒全麻时人血浆β－内啡肽（β－ＥＰ）水平的变化。方法：４０名全麻手术患者随机分成四组，手术结束时每组分别静注催醒宁、氨茶碱、胃复安或美解眠，采用放射免疫法测定用药前后患者血浆中β－ＥＰ含量。结果：上述药物在产生催醒作用的同时患者血浆β－ＥＰ水平也呈显著升高，其中催醒宁组升高６８％，氨茶碱组６３％，胃复安组５２％，美解眠组４６％（Ｐ＜０．０１）。Objective: To investigate the effects of “705”, aminophyline, metoclopramide or megimidum on the plasma β endorphine (β EP) during awakening the patients under general anesthesia. Method: Forty general anesthesia patients were divided randomly into four groups and administrated iv one of the four drugs at the end of operation. Plasma β endorphine was measured by RIA. Results: Plasma β EP levels were significantly increased by 68% (705 group), 63%(aminophyline),52%(metoclopramide)and 46%(megimidum)( P< 0 01). Conclusion: The reversal of general anesthesia status is closely correlated with both of excitation of the central cholinergic nerve system and the concentration of plasma β endorphine.

关 键 词：催醒剂 Β-内啡肽 全身麻醉 催醒宁 

分 类 号：R614.2[医药卫生—麻醉学]