急性长时间运动对大鼠心肌线粒体功能的影响  

The Effects of Mitochondrial Function in Myocardiocytes After an Acute Bout of Strenuous Exercise in Rats

作　　者：高彩暇[1] 

机构地区：[1]淮阴师范学院体育学院,江苏淮安223300

出　　处：《淮阴师范学院学报（自然科学版）》2009年第4期337-340,共4页Journal of Huaiyin Teachers College;Natural Science Edition

摘　　要：探讨了急性长时间运动对大鼠心肌线粒体功能的影响.将8周龄大鼠雌性SD大鼠12只随机分成对照组(6只)和运动组(6只),运动组负重游泳299±29 min后立即处理取心肌线粒体测定线粒体RCR,线粒体抑制活性氧的能力以及[Ca2+]i.结果表明,一次性长时间运动后,大鼠心肌线粒体抑制活性氧(O2-.,OH)的能力下降(p<0.05),但线粒体呼吸功能完好(p>0.05),线粒体游离钙离子浓度没有发生变化(p>0.05).急性长时间运动产生的氧自由基还不足以攻击心肌线粒体.To study the effects of mitochondrial function in myocardio cytes after acute bout of strenuous exercise in rats. Methods： Put twelve 8-wee k s-old female SD rats randomly divide into contrast group （six） and exercise gro u p （six）, then let the fads of exercise group swim with heavy swam 299 ± 29 min av eragely, then killed to get myocardium mitochondria to measure mitochondria RCR, the ability of mitochondria＇ s restrain to radical oxygen species（ROS） and [Ca^2＋ ]i. Results： although the ability of rats＇ mitochondfial restrain to R eactive Oxygen Species （ O2^-·, OH ） decreased （p 〈 0.05）, but rats＇ myecardium m itochondrial respiration controlling rate was complete （p 〉 0.05）, the concentrat i on of mitochondria free Ca^2＋ was not changed（p 〉 0.05） after an acute bout o f strenuous exercise. Conclusion： Produced ROS by an acute bout of strenuous exercise are＇ t enough to attack myocardiocyte mitechondria.

关 键 词：运动 心肌线粒体 呼吸控制率 活性氧 大鼠 动物实验 

分 类 号：G804.7[文化科学—运动人体科学]