人膝关节软骨与聚乙烯醇水凝胶人工软骨压缩实验比较研究  

Study on the compression properties between articular cartilage and polyvinyl alcohol hydrogel as artificial cartilage

作　　者：李锋[1] 周海宇[1] 苏永琳[1] 王成焘[1] 

机构地区：[1]上海交通大学机械与动力工程学院,上海200240

出　　处：《医用生物力学》2009年第6期448-451,457,共5页Journal of Medical Biomechanics

基　　金：国家自然科学基金(50535050)

摘　　要：目的比较人膝关节软骨和聚乙烯醇水凝胶(PVA-H)人工软骨的生物力学性能。方法使用人膝关节软骨和PVA-H人工软骨进行轴向压缩试验,分别进行压缩应力应变、应力松弛和蠕变实验,得到关节软骨和PVA-H人工软骨的应力应变关系。结果实验中人关节软骨和PVA-H的力学性能有差异,人关节软骨压缩模量大于PVA-H人工软骨,人关节软骨的压缩模量为(3.6492±0.6199)Mpa,PVA-H的压缩模量为(1.5951±0.1469)Mpa。结论软骨和PVA-H人工软骨的生物力学性能具有一定差异,试验结果对人工软骨的进一步改进具有指导意义。Objective To compare the compression properties of articular cartilage and polyvinyt alcohol hydrogel （PVA-H） as artificial cartilage. Method Unconfined compression tests were conducted on articular cartilage and PVA-H, including stress-strain tests, creep tests and stress relaxation tests. The stress-strain relationship of articular cartilage and PVA-H were measured. Result The compression modulus of articular cartilage was higher than that of PVA, hydrogel. The average compression modulus of articular cartilage and PVA hydrogel was （3.6492 ±0.6199） Mpa and （1.5951±0.1469）Mpa, respectively. Conclusions The experimental results revealed the differences existed between articular cartilage and PVA-H and this would be useful to further improve the mechanical properties of artificial cartilage.

关 键 词：力学性能 关节软骨 水凝胶 

分 类 号：R318.01[医药卫生—生物医学工程]