甲氧滴滴涕对小鼠骨质疏松的影响  

Effects of methoxychlor on bone loss(osteroporosis) in mice

作　　者：宫海丹[1] 陈必良[1] 张建芳[1] 马佳佳[1] 

机构地区：[1]第四军医大学西京医院妇产科,陕西西安710033

出　　处：《第四军医大学学报》2009年第24期3033-3036,共4页Journal of the Fourth Military Medical University

摘　　要：目的:探讨甲氧滴滴涕(MXC)对小鼠骨质疏松的影响.方法:将40只昆明小鼠随机分为50,100,200mg/(kg.d)组及溶剂芝麻油组(对照组),连续14d给予灌胃染毒MXC,末次给予MXC24h内处死小鼠,取肝、脾、胸腺称质量,取左侧股骨进行骨组织形态学观察,并取右侧股骨进行骨干质量、骨钙及骨羟脯氨酸(B-HOP)的测定和比较.结果:不同剂量MXC分别致小鼠骨干质量减少,骨横短径减少,骨钙及骨羟脯氨酸含量减少和胸腺萎缩.结论:MXC可引起小鼠以骨量丢失为主的骨质疏松.AIM：To investigate the effects of methoxychlor（MXC） on bone loss（osteroporosis） in mice.METHODS：MXC was administrated to the mice at doses of 0（control）,50,100 and 200 mg/（kg·d） via oral gavage for consecutive 14 d,then mice were euthanized.The thymus,liver and the spleen were weighted separately;then observed the morphology of the effects of MXC on left femur.At the end,took the bone histomorphomerey,bone hydroxyproline（B-HOP） and bone calcium to make the measurement and comparison.RESULTS：Compared with normal control mice,three doses of MXC can induce the decrease of femoral bone weight and the short transverse diameter.Bone-hydroxyproline content decreased remarkably,so did the bone-Ca.The thymus of the mice were atrophy.CONCLUSION：Three dosages of retinoic acid in mice can induce osteoporosis with the lessening of bone mass.

关 键 词：甲氧滴滴涕 骨质疏松 骨羟脯氨酸 骨钙 

分 类 号：R322.71[医药卫生—人体解剖和组织胚胎学]