糖尿病性心肌病患者GLP-1与C-反应蛋白的相关性分析  

Correlation between GLP-1 and CRP in patients with diabetic cardiomyopathy

作　　者：金爱萍[1] 许谌 张岁龙[1] 

机构地区：[1]西安交通大学第二医院老年病科,陕西西安710004 [2]西安市第二医院,陕西西安710003

出　　处：《第四军医大学学报》2009年第24期3123-3125,共3页Journal of the Fourth Military Medical University

摘　　要：目的:通过观察糖尿病性心肌病患者的胰高血糖素样肽-1(GLP-1)与炎性因子的相关性,探讨其在糖尿病性心肌病发病机制中的作用.方法:测定50例糖尿病心肌病患者(实验组)和30例健康者(对照组)的血清GLP-1、超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、血压、空腹血糖、餐后2h血糖(2hPG)、空腹血清胰岛素(FINS),计算稳态模型评价胰岛素抵抗指数(HOMA-IR).结果:实验组空腹血糖、2hPG、收缩压、FINS、HOMA-IR、hs-CRP、IL-6和TNF-α均显著高于对照组(P<0.05),血清GLP-1显著低于对照组(P<0.05);GLP-1水平与hs-CRP(r=0.556,P=0.002)和HOMA-IR(r=0.445,P=0.007)呈显著负相关.结论:糖尿病性心肌病的发生发展是GLP-1、炎性因子、胰岛素抵抗等多因素综合作用的结果.AIM：To investigate the correlation between glucagon like peptides-1（GLP-1） and inflammatory cytokines and evaluate mechanism of diabetic cardiomyopathy.METHODS：Serum GLP-1,hyper sensitive C-reactive protein（hs-CRP）,interleukin-6（IL-6）,tumor necrosis factor-α（TNF-α）,blood pressure,fasting plasma glucose,2 h plasma glucose（2hPG）,fasting serum insulin（FINS） and homeostasis model assessment insulin resistance（HOMA-IR） were measured in 50 patients with diabetic cardiomyopathy（experimental group） and 30 healthy persons（control group）.RESULTS：Compared with control group,fasting plasma glucose,2hPG,systolic pressure,FINS,HOMA-IR,hs-CRP,IL-6 and TNF-α were significantly increased（P0.05）,while serum GLP-1 were reduced in experimental group（P0.05）;serum GLP-1 were negatively correlated with hs-CRP（r=0.556,P=0.002） and HOMA-IR（r=0.445,P=0.007）.CONCLUSION：The occurance and development of diabetic cardiomyopathy is decided by interrelation of GLP-1,inflammatory cytokines and insulin resistance.

关 键 词：糖尿病性心肌病 胰高血糖素样肽-1 超敏C反应蛋白 

分 类 号：R542.2[医药卫生—心血管疾病]