宣威肺癌高发区室内PM_(10)的生物活性研究  

Investigation of the bioreactivity of indoor PM_(10) in Xuanwei,China

作　　者：周林[1] 邵龙义[1] 宋晓焱[1] 刘君霞[1] 

机构地区：[1]中国矿业大学(北京)地球科学与测绘工程学院,北京100083

出　　处：《毒理学杂志》2009年第6期439-441,共3页Journal of Toxicology

基　　金：国家自然科学基金项目基金(40672103)

摘　　要：目的研究宣威肺癌高发地区室内可吸入颗粒物(PM10)的生物活性。方法采集宣威肺癌高发区虎头村和肺癌低发区宁家湾村冬季室内可吸入颗粒物样品,采用质粒DNA评价法(Plasmid DNA assay)评价PM10的生物活性,并利用电感耦合等离子体质谱(ICP-MS)对PM10的微量元素进行分析。结果虎头村室内PM10的生物活性高于对照组宁家湾村,结合微量元素分析发现,虎头村PM10的TD20值与锌(Zn)、铅(Pb)、镉(Cd)、砷(As)等水溶性微量元素的含量具有一定相关性,其中金属元素Zn和Pb与生物活性的相关性较其他元素强。结论在本试验条件下,水溶性过渡金属Zn、Pb等可能是导致虎头村室内PM10具有较高生物活性的重要因素。Objective To investigate the bioreactivity of indoor PM_10 in Xuanwei,China,where the mortality rate of Xuanwei lung cancer ranked first in China and there were clear regional differences.Methods Plasmid DNA assay was employed to investigate the bioreactivity of the indoor PM_10 collected from high and low incidence area of lung cancer respectively in Xuanwei Town.Results Comparison of the two groups suggested that the bioreactivity of the indoor PM_10 collected from Hutou village was higher than that of the control group;The ICP-MS result suggested that the consistency of water-soluble zinc and plumbum had a positive correlation with the DNA damage rates.Conclusion It signifi that the water-soluble zinc and plumbum may be an important factor of the high bioreactivity of the Hutou indoor PM10.

关 键 词：可吸入颗粒物 质粒DNA评价法 肺癌 生物活性 

分 类 号：X513[环境科学与工程—环境工程]