冠心病血糖异常患者炎症因子与糖化血红蛋白的关系  

Relation Between Glycosylated HemoglbinA1c and Inflammatory Factors in Patients with Coronary Heart Disease

作　　者：张元春[1] 罗常有[1] 尹庆[1] 吴家宽[1] 孙金玲[1] 

机构地区：[1]中山大学附属东华医院心血管内科,广东省东莞市523110

出　　处：《中国动脉硬化杂志》2009年第11期925-928,共4页Chinese Journal of Arteriosclerosis

基　　金：东莞市科学技术局资助项目(2007105150053)

摘　　要：目的探讨冠心病血糖异常患者血炎症因子特点及其与糖化血红蛋白的关系。方法对经临床和冠状动脉造影确诊为冠心病的203例患者全部行糖耐量试验,然后按血糖水平分成糖尿病组(68例)、糖调节异常组(80例)及血糖正常组(55例)。分析比较三组血白细胞、纤维蛋白原和C反应蛋白水平及其与糖化血红蛋白的关系。结果糖尿病组和糖调节异常组患者血白细胞、纤维蛋白原和C反应蛋白水平均较血糖正常组升高(均P<0.05)。血清糖化血红蛋白水平与血白细胞(R2=0.158 9,P<0.05)、血清C反应蛋白(R2=0.228 5,P<0.05)和纤维蛋白原(R2=0.302 4,P<0.05)水平呈正相关趋势。结论糖尿病和糖调节异常冠心病患者合并更严重的系统性炎症反应。Aim To approach the relationship between inflammatory factors and glycosylated hemoglbinA1c（HbA1c） in patients with coronary heart disease（CHD）. Methods 203 consecutive patients with CHD was recruited and took oral glucose tolerance test（OGTT）.68 cases suffered from diabetes mellitus（DM）,80 from impaired glucose homeostasis（IGH） and 55 were with normal glucose.White blood cell（WBC）,fibrinogen（FIB）,and C-reactive protein（CRP） were compared among the three groups.The relation between WBC,FIB,CRP and HbA1c was analyzed. Results Patients with DM or IGH had a higher level of WBC（P〈0.05）,FIB（P〈0.05） and CRP（P〈0.05） compared with the normal glucose.There was statistic positive relation between WBC（R2=0.158 9,P〈0.05）,CRP（R2=0.228 5,P〈0.05）,FIB（R2=0.302 4,P〈0.05）and HbA1c. Conclusion Patients of CHD with DM and IGT suffer a more severe system inflammation.

关 键 词：糖尿病 糖调节异常 炎症因子 糖化血红蛋白 冠心病 

分 类 号：R5[医药卫生—内科学]