细菌脂多糖的生物活性及作用机制  

Biological Activity and Mechanism of Bacterial Lipopolysaccharide

作　　者：刘中原[1] 李延平[2] 

机构地区：[1]广东医学院药理学教研室,广东湛江524023 [2]广东医学院天然药物研究与开发实验室,广东湛江524023

出　　处：《医学综述》2010年第2期166-169,共4页Medical Recapitulate

基　　金：广东省教育厅自然科学研究项目(04J005)

摘　　要：细菌脂多糖(LPS)或细菌内毒素能引起内毒素血症、脓毒症等疾病。近年来,有关LPS的研究备受关注,LPS在机体细胞内的作用机制为研究重点。研究表明,LPS与细胞膜上相应受体作用后,启动胞内信号传递链,引起核因子κB等活化,启动基因转录,表达和释放多种细胞因子,发挥其毒性作用。而微量的LPS能够活化单核巨噬细胞系统,促进细胞因子释放,促进补体的活化和抗体的产生,对特异性免疫反应具有调节作用。Bacterial lipopolysacchar-ide（LPS） or bacterial endotoxin, can cause endotoxemia, sepsis and other diseases. Researches in recent years have drawn greater attention to LPS. LPS in the intracellular mechanisms were the research emphasis. Studies have shown that LPS can start intracellular signal transduetion chain and cause nuclear transcription factor κB and so on activation after effecting with the corresponding receptors on the cell membrane, and switch on gene transcription, express and release a variety of eytokines, play toxic effects -of LPS. The small amount of LPS can activate monocytemacrophage system ,promote the release of eytokines, complement activation and antibody production, had the role of regulating specific immune response.

关 键 词：细菌脂多糖 毒性 生物活性 受体 

分 类 号：R329.1[医药卫生—人体解剖和组织胚胎学]