甲状腺功能减退与动脉粥样硬化  

The Progress of the Relationship between Hypothyroidism and Atherosclerosis

作　　者：于园[1] 段宇[1] 

机构地区：[1]南京医科大学第一附属医院内分泌科,南京210029

出　　处：《医学综述》2010年第2期259-262,共4页Medical Recapitulate

摘　　要：心脏是甲状腺激素的重要靶器官之一,甲状腺功能异常可导致多种心血管并发症的出现,而在甲状腺功能减退即甲状腺激素分泌不足的状态下,脂质代谢紊乱产生的高脂血症、血管内皮细胞功能障碍引起的凝血及血管屏障功能改变、血管平滑肌细胞舒张性下降导致的舒张期高血压及激活的脂质过氧化反应等因素,均可影响心血管系统的功能,促进动脉粥样硬化的发生与发展。Cardiovascular system is an important target of thyroid hormone. Thyroid dysfunction may lead to variety of cardiovascular complications. In the status of hypothyroidism, Hyperlipidemia induced by dyslipidemia, abnormal coagulability induced by endothelial dysfunction, diastolic hypertension induced by the vascular smooth muscle cell dysfunction,and activated lipid peroxidation may affect the function of the cardiovascular system,and promote the occurrence and development of atherosclerosis.

关 键 词：甲状腺功能减退 动脉粥样硬化 血脂异常 高血压 氧化应激 

分 类 号：R581[医药卫生—内分泌]