哮喘患者诱导痰中TSLP、IL-25水平测定及意义  

Detection and significance of TSLP,IL-25 levels in the sputum of asthmatic patients

作　　者：周士霞[1] 王起龙[2] 袁彦丽[1] 康燕[1] 张辉[1] 张春玲[1] 王静[1] 

机构地区：[1]郑州大学第一附属医院,郑州450052 [2]郑州大学临床医学系

出　　处：《山东医药》2010年第3期31-32,共2页Shandong Medical Journal

摘　　要：目的探讨胸腺基质淋巴细胞生成素(TSLP)、IL-25在支气管哮喘(下称哮喘)发病中的作用。方法选择急性发作期及慢性期哮喘患者各15例(哮喘组)及健康查体者15例(对照组),采用超声雾化吸入4%高渗盐水法采集诱导痰标本,以ELISA法测定诱导痰中TSLP、IL-25水平,分析两者相关性。结果哮喘组诱导痰中TSLP及IL-25水平均显著高于对照组,且急性发作期显著高于慢性期(P均<0.05)。结论TSLP、IL-25可能在哮喘发生、发展中具有重要作用,有望作为哮喘治疗的潜在靶点。Objective To investigate the roles of thymie stromal lymphopoietin （TSLP）, interleukin （IL）-25 in the occurrence of bronchial asthma. Methods Patients with asthma（ asthma group） in exacerbation and chronic stage （ 15 cases in each） and 15 healthy controls（control group） were involved ,then the induced sputum were collected by ultrasonic atomizing inhalation of 4% hypertonie saline solution,TSLP and IL-25 in which were examined by ELISA and correlations between the two indexes were analyzed. Results Levels of TSLP and IL-25 in asthma group were significantly higher than those in the control group, and which in the exacerbation were obviously higher than those in the chronic stage（P 〈 0.05 ）. Conclusion TSLP and IL-25 may play important roles in the occurrence and development of asthma, and is likely to be a potentiaharget for the treatment of asthma.

关 键 词：胸腺基质淋巴细胞生成素 白细胞介素-25 哮喘 气道炎症 

分 类 号：R562.2[医药卫生—呼吸系统]