一氧化氮与高原肺功能  

RELATIONSHIP BETWEEN NITRIC OXIDE AND PULMONARY FUNCTION AT HIGH ALTITUDE

作　　者：马勇[1] 张西洲[1] 李新菊[1] 王伟[1] 闫相华[1] 

机构地区：[1]解放军第十八医院

出　　处：《高原医学杂志》1998年第3期32-33,共2页Journal of High Altitude Medicine

摘　　要：目的：探讨一氧化氮（ＮＯ）对急进高海拔地区早期肺通气功能的改善调节作用，探索急性高原病“易感期”人群的有效预防手段及途径。方法：对从平原（１４００ｍ）急进海拔５３８０ｍ（４天内抵达）第三天的２０名健康青年在静息状态下进行了ＮＯ吸入前后的肺功能，血氧饱和度（ＳｐＯ２）和心率（Ｐ）的测定。结果：急进者静息状态下的肺通气功能、ＳｐＯ２均值普遍低于平原健康人，ＮＯ吸入后，时间肺活量（ＦＶＣ）１秒用力呼气量（ＦＥＶ１）、ＦＥＶ１％（ＦＥＶ１／ＦＶＣ），用力吸气中期流速（ＦＥＦ２５％～７５％）、最大呼气流量（ＰＥＦ）、最大通气量（ＭＶＶ）与ＮＯ吸入前比较有显著提高（Ｐ＜０．０１或Ｐ＜０．０５）。ＳｐＯ２提高非常显著（Ｐ＜０．０１），Ｐ降低非常显著（Ｐ＜０．０１）；结论：吸入ＮＯ对高原急性缺氧期的肺通气功能及ＳｐＯ２有显著的改善和调节作用。Objectice:To study effects of NO on ventilation of lung in healthy young mem acutely exposed to high altitude early and process to prevent acute high altitude desease in susceptible stage.Methods:The pulmonary function,SpO 2 and P were measured at rest in 20 healthy subjects acutely explsed to high altitude ( 5 380m )from 1 400m altitude,experience four days travel,on the third postaltitude day before and after inspiring NO.Results:Meanlevel of pulmonary ventilation fuction and SpO 2 were lower than control before inspiring NO.FVC,FEV 1,FEV 1/FVC,FEF25%～75%,PEF and MVV increased significantly after inhaling NO( P <0 01 or P <0 05),specially SpO 2 increased greatly( P <0 01)and P discreased greatly( P <0 01).Conclusions:There is a effects of improvement when NO is inhaled by subjects exposed to high altitude and the mechonism of NO on high altitude hypoxia is explored clearly.

关 键 词：肺功能 一氧化氮 高原 缺氧 

分 类 号：R594.3[医药卫生—内科学]