血压盐敏感性有关因素的研究  

The Study of the Related Factors of the Salt-sensitivity

作　　者：张竞超[1,2,3] 张安玉[1,2,3] 张欣 李连荣[1,2,3] 武光林 黄体刚 张毅华[1,2,3] 谢婷婷 

机构地区：[1]天津医科大学公共卫生学院 [2]天津市心脏病研究所 [3]天津钢厂医院

出　　处：《中国慢性病预防与控制》1998年第5期231-234,共4页Chinese Journal of Prevention and Control of Chronic Diseases

摘　　要：应用公认的确定盐敏感性的方法检出一定数量的盐敏感者和不敏感者，用病例（盐敏感者）对照（盐不敏感者）研究方法对比分析他们的特征，确定与盐敏感相关最显著的指标，为今后筛选盐敏感者方法提供基础。单因素分析结果表明：在原发性高血压病人组，盐敏感性与基线、钠饱和期及钠消耗期红细胞钠／锂反运转率，钠消耗期尿钠排泄量、钠消耗期血浆醛固酮水平等有关，对可能混杂变量进行调整，用非条件Ｌｏ－ｇｉｓｔｉｃ回归模型分析，结果表明只有基线钠／锂反运转率被引入主效应方程，提示了它是盐敏感性的重要筛选指标。The present study used a standardized protocol of intravascular volume expansion and contraction to identify salt sensitive(SS) and resistant individuals, then compared and analyzed the characteristic of salt sensitivity by use of the case control study to find out salt sensitivity related indicators for providing the basic data on screening method of salt sensitivity. The results of single factor analysis showed that SS was closely related to the three factors:①Na +/Li +CT(countertransport) during baseline, sodium loading, and sodium and volume depletion,②plasma aldosterone concentrations during sodium and volume depletion,③sodium excretion during sodium and volume depletion. Based on single factor analysis, the joint effect of related factors was examined with unconditional Logistic regression model. The result showed that only Na +/Li +CT of baseline was got into the equation.

关 键 词：原发性 高血压 盐敏感 钠锂反运转率 

分 类 号：R544.1[医药卫生—心血管疾病]