疏水化多糖对脂质体稳定性的增强作用  

HYDROPHOBIC POLYSACCHARIDE ENHANCE ACTION OF LIPOSOME STABILITY

作　　者：张振涛[1,2] 吴仁奇[1,2] 侯新朴 

机构地区：[1]内蒙古医学院化学教研室 [2]北京医科大学

出　　处：《内蒙古医学院学报》1998年第3期172-174,共3页Acta Academiae Medicinae Neimongol

摘　　要：目的：测定疏水化多糖对脂质体稳定性的增强作用。方法：采用钙黄绿素（ｃａｌｅｉｎ）和１，８－ＡＮＳ荧光物质包载于脂质体内，采用荧光分光光度法，通过测定荧光强度，确定渗漏率。另以磷脂酶Ｄ为水解物，测定渗漏率。结果：疏水化多糖对脂质体的包载物的渗漏有明显的抑制作用，对磷脂酶Ｄ引起的磷脂水解渗漏亦有显著的抑制作用。结论：疏水化多糖对于提高脂质体的稳定性有重要作用。Objective:To determine the effects of hydrophobic polysaccharide on liposome stability.Methods:The calcein and ANS were encapsulated into liposome respectively.The rate of leakage was determined by measuring the fluorometric intensity.In the same way,with phospholipase D as hydrolase,the rate of leakage was determined too.Results:The results showed that hydrophobic polysaccharide could inhibit leakage from liposome significantly.The results also suggested that hydrophobic polysaccharide could inhibit hydrolysis rate by phospholipase D.Conclusion:The hydrophobic polysaccharide had important action to enhance the liposome stability.

关 键 词：硬脂酰葡聚糖 脂质体 稳定性 

分 类 号：TQ460.4[化学工程—制药化工]