抗精神病药物对乙肝病毒感染患者肝功能影响的对照研究  

A comparative study on liver function of patients with HBV infection during antipsychotic medications

作　　者：徐向东[1] 吕淑云[1] 杨永谊 贾新生[1] 倪红[1] 贺庆芝[1] 

机构地区：[1]新疆石河子绿洲医院

出　　处：《四川精神卫生》1998年第1期21-23,共3页Sichuan Mental Health

摘　　要：目的许多研究认为抗精神病药物可导致肝损害，但还不清楚服用抗精神病药物的同时乙肝病毒感染对肝功能的影响，及抗精神病药物是否会加重肝损害。方法本文对照研究了抗精神病药物对乙肝病毒感染（ＨＢＶ）、未感染和曾感染但已恢复的精神分裂症患者肝功能的影响。结果我们发现三组肝功能异常发生率（１９％、２３％和２０％）无显著性差异，抗精神病药物所致肝损害与是否存在乙肝病毒感染无关。结论抗精神病药物所致肝损害除变态反应外可能还有直接细胞毒效应。Objective Many studies suggest that antipsychotic medications may cause liver dysfunction,but it is still unclear that whether HBV infection affects liver function of patients integrate with psychotic medications,and whether antipsychotic medications deteriorate liver function of patients with HBV infection.Method So we made a comparative study on liver function during antipsychotic medications among patients with HBV infection,without HBV infection and patients having recovered from HBV infection.Results Rates of liver dysfunction were 19%,23%and 20% respectively among 3 groups,without significant differences.Conclusions The study suggested that antipsychotic medications did cause liver dysfunction and their short term effect might be greater than that of HBV infection on liver function.These 2 factors showed no double effect on liver function.

关 键 词：抗精神病药物 乙肝病毒 肝功能 对照研究 

分 类 号：R971.4[医药卫生—药品]