维生素E对慢性肾功能衰竭患者肾纤维化的影响  

Effect of vitamin E on renal fibrosis in chronic renal failure patients

作　　者：朱丽[1] 侬光彪[1] 

机构地区：[1]云南省文山州人民医院肾内分泌科,663000

出　　处：《疑难病杂志》2010年第2期105-106,共2页Chinese Journal of Difficult and Complicated Cases

摘　　要：目的观察维生素E对慢性肾功能衰竭患者肾纤维化的影响。方法将74例慢性肾功能衰竭患者随机分为2组,对照组37例按常规治疗,治疗组37例在常规治疗基础上加用维生素E,治疗3个月后观察2组血清肌酐(Scr)、尿素氮(BUN)、内生肌酐清除率(Ccr)和层黏连蛋白(LN)、透明质酸(HA)、Ⅲ型前胶原(PC-Ⅲ)、Ⅳ型胶原(Ⅳ-C)等指标的的改变情况。结果与治疗前比较,2组血清Scr、BUN、LN、HA、PC-Ⅲ、Ⅳ-C水平均降低,Ccr均提高,且除LN外,治疗组各项指标均优于对照组,差异有统计学意义(P<0.05)。结论维生素E能抑制肾纤维化,延缓慢性肾功能衰竭的进程。Objective To study the effect of vitamin E on renal fibrosis in chronic renal failure （CRF） patients. Methods 74 patients were screened and randomly divided into two groups： treatment group and control group. In control group,37 cases were treated by conventional treatment,and the cases in treatment group （ n = 37 ） were added vitamin E beyond conventional therapy. Then serum creatinine （Scr）, blood urea nitrogen （BUN）, endo genous creatinine clearance rate （Ccr） and laminin （ LN ）, hyaluronic acid （ HA ）, Ⅲ procollagen （ PC-Ⅲ ） , Ⅳcollagen （Ⅳ-C） were detected. Results Compared with those before treatment, Scr, BUN, LN, HA, PC-Ⅲ, Ⅳ-C were significantly lowered in both groups, and Ccr increased, treatment group were obviously better than those of control group except LN（ P 〈 0.05）. Conclusion Vitamin E could suppress renal fibrosis, and delay the chronic renal fai lure process.

关 键 词：肾功能衰竭 慢性 肾纤维化 维生素E 

分 类 号：R692.5[医药卫生—泌尿科学] R977.25[医药卫生—外科学]