厄贝沙坦对糖尿病肾病大鼠ICAM-1表达的影响  

Effects of Irbesartan on Expressions of ICAM-1 in Rats with Diabetic Nephropathy

作　　者：李佃淳[1] 刘利生[2] 刘锦秀[2] 胡怀霞[2] 

机构地区：[1]江苏省连云港市东方医院肾内科,222042 [2]连云港市第二人民医院东院区肾内科,222006

出　　处：《中华全科医学》2010年第2期138-139,F0003,共3页Chinese Journal of General Practice

摘　　要：目的从影响细胞间粘附分子-1(ICAM-1)表达的角度,探讨厄贝沙坦对实验性糖尿病大鼠肾脏的保护作用及其可能机制。方法SD健康大鼠24只,随机分为对照组、模型组、药物组,每组8只。链脲佐菌素(STZ)诱导糖尿病大鼠模型,药物组大鼠每日给予厄贝沙坦150mg/kg体重灌胃,持续6周。6周后抽血测血糖(BG),糖化血红蛋白(HbA1c),尿素氮(BUN),肌酐(Scr);测定24h尿微量白蛋白(mAlb),计算尿白蛋白排泄率(UAER)。处死SD大鼠,取其肾脏,用免疫组化方法检测ICAM-1。结果模型组与药物组的BG、HbA1c、BUN、Scr都高于对照组,上述指标在模型组与药物组之间差异无统计学意义。模型组UAER高于对照组,而药物组则低于模型组。药物组ICAM-1蛋白表达量低于模型组。结论厄贝沙坦对实验性糖尿病大鼠的肾脏有保护作用,其机制可能与抑制ICAM-1在肾脏的表达有关。Objective To investigate the protective effects and mechanism of irbesartan on the kidneys of diabetic rats from the perspective of studying the expression of intercellular adhesion molecule-1（ICAM-1）.Methods Twenty-four male SD rats were randomly and equally divided into control group,model group and treatment group（n=8 each）.The rat model of DN was induced by injection of streptozocin（STZ）.The rats of treatment group were fed with irbesartan.Six weeks later,BG,HbA1c,BUN,Scr,mAlb,UAER were measured.The expressions of ICAM-1 were observed by immunohistochemistry.Results The levels of BG,HbA1c,BUN and Scr in model group were higher than those in control group.Compared with model group,the levels of them did not decrease significantly in treatment groups.UAER in model group was higher than that in treatment group.The expression of ICAM-1 in treatment group decreased significantly as compared with that of model group.Conclusion Irbesartan has renal protective effects on kidney of diabetic rats.This effect may be achieved by decreasing the expressions of ICAM-1.

关 键 词：糖尿病肾病 厄贝沙坦 细胞间粘附分子-1 

分 类 号：R587.24[医药卫生—内分泌] R392.114[医药卫生—内科学]