NT-proBNP与心肌缺血关系的初步探讨  

A Preliminary Study on the Relationship between NT-proBNP and Myocardial Ischemia

作　　者：林茂欢[1] 王景峰[1] 刘香梅[2] 黄至斌[1] 谢双伦[1] 周淑娴[1] 聂如琼[1] 

机构地区：[1]中山大学附属第二医院心内科,广东省广州市510120 [2]中山大学附属第二医院检验科,广东省广州市510120

出　　处：《中华全科医学》2010年第2期165-167,共3页Chinese Journal of General Practice

摘　　要：目的探讨NT-proBNP与冠心病心肌缺血间的关系。方法用电化学发光方法检测73例冠心病患者入院NT-proBNP浓度,对其中37例行择期PCI的患者再检测术前、术后24小时NT-proBNP浓度。结果冠心病患者血NT-proBNP浓度随着临床分型、冠脉受累支数、冠脉狭窄程度的加重而升高;择期PCI术后血NT-proBNP浓度降低,术前lg(NT-proBNP)为(2.85±0.74)pg/ml,术后lg(NT-proBNP)为(2.64±0.77)pg/ml(P<0.01)。结论NT-proBNP与冠心病心肌缺血间存在密切的关系,NT-proBNP是冠心病心肌缺血严重程度的一个有效标志物。Objective To investigate the relationship between NT-proBNP and myocardial ischemia.Methods 73 patients with CHD were enrolled,baseline NT-proBNP levels were assigned by using electrochemiluminescence,and the NT-proBNP levels before and 24 hours after the procedure were also assigned in 37 patients who had undergone elective PCI.Results The concentrations of NT-proBNP correlated with the severity of ischemia,elective PCI reduced the concentrations of NT-proBNP from （2.85±0.74）pg/ml before PCI to （2.64±0.77）pg/ml after the procedure（P0.01）.Conclusion NT-proBNP was closely correlated with myocardial ischemia,it can be served as a effective biomarker of myocardial ischemia.

关 键 词：钠尿肽 心肌缺血 冠状动脉 血管成形术 

分 类 号：R542.22[医药卫生—心血管疾病] R654.33[医药卫生—内科学]