温经通络熏洗方治疗DPN疗效观察及机理探讨  

Effect Observation and Mechanism Investigation of Wenjing Tongluo Xunxi Fang on DPN

作　　者：李金花[1] 李惠林[1] 赵恒侠[1] 刘燕平[1] 李增英[1] 

机构地区：[1]深圳市中医院,广东深圳518033

出　　处：《世界中西医结合杂志》2010年第1期51-53,共3页World Journal of Integrated Traditional and Western Medicine

基　　金：广东省深圳市科技局产项课题(No.20070326)

摘　　要：目的探讨温经通络熏洗方治疗糖尿病周围神经病变(DPN)的临床疗效。方法将符合病例标准的DPN患者80例,随机分为两组,每组40例。对照组口服弥可保,治疗组采用温经通络熏洗方治疗。观察两组患者空腹及餐后2 h血糖、糖化血红蛋白、红细胞醛糖还原酶(RBC-AR)、红细胞Na-K-ATPase活性、腓总神经运动神经传导速度(MNCV)、腓肠神经感觉神经传导速度(SNCV)以及临床症状改善情况。结果温经通络熏洗方对DPN患者的症状、体征及相关实验室检查均有不同程度的改善,总有效率为92.5%,与对照组比较有显著性差异(P<0.05)。治疗组临床证候和RBC-AR、红细胞Na-K-ATPase活性,治疗前后及与对照组比较有显著性差异(P<0.05,P<0.01)。血糖及HbAlc治疗后其绝对值均有所下降,但与对照组比较无显著性差异(P>0.05)。结论本研究证实温经通络熏洗方在不影响血糖的情况下,治疗DPN疗效显著。Objective To explore the clinical efficacy of Wenjing Tongluo Xunxi Fang on diabetic peripheral Neuropathy（DPN）. Methods 80 DPN cases were selected according to diagnostic criteria and were randomly divided into 2 groups ,40 cases in each one. In control group, mecobalamin was administered orally. In treatment group, Wenjing Tongluo Xunxi Fang was applied. FBG, 2hPBG, HbAlc, RBC -AR, RBC Na - K - ATPase activity, motor nerve conduction velocity （MNCV） of common peroneal nerve and sensory nerve conduction speed（SNCV） of sural nerve as well as the clinical symptom improvements were observed in two groups. Results Wenjing Tongluo Xunxi Fang achieved the improvements of different degrees in symptoms,physical signs and relevant laboratory examinations of DPN patients. The total effective rate was 92. 5%. Significant difference was presented in comparison with control group （P 〈 0.05 ）. In treatment group, the changes in the clinical symptoms, RBC - AR, RBC Na - K - ATPase activity before and after treatment are different significantly compared with those in control group（P 〈 0.05 or P 〈 0.01 ）. The absolute values of blood glucose and HbAle decreased ＇after treatment, but there was no significant difference in comparison with control group （P 〉 0.05）. Conclusion The research confirms that Wenjing Tongluo Xunxi Fang achieves significant efficacy on DPN without the disturbance of blood glucose.

关 键 词：糖尿病周围神经病变 温经通络熏洗方 机理 

分 类 号：R277.751.2[医药卫生—中医学] R735