以BALB/C小鼠作抗麻风药物的实验研究  

MALB/C Mouse Model in Screening of Antileprosy Drugs

作　　者：熊俊浩[1] 喻林冲[1] 

机构地区：[1]四川省皮肤病性病防治研究所

出　　处：《中国麻风杂志》1998年第3期142-143,共2页

摘　　要：用取自两列新发现的Ｌ型病人的麻风菌，接种于ＢＡＬＢ／Ｃ纯系小鼠的后足垫。接种菌量为５×１０＾３／足垫。实验组小鼠分别喂含有０．０００１％、０．００％或０．０１％的ＤＤＳ，或０．０５％的Ｂ６６３的食物，或者含有ＲＦＰ２０ｇ／Ｌ的琼脂水。后者每周喂１次。接种后６个月，对照组小鼠足垫中的菌量达到２．５×１０＾５，而实验组除用ＲＦＰ的５只鼠中的１只外，全部足垫中都无麻风菌可见。作者认为此小鼠价廉、易饲养、Leprosy bacilli taken from two newly detected patients with lepromatous leprosy have been inoculated into the rear foot pads of BALB/C pure bred mice. The contents of inoculat- ed bacilli were 5×10~3 per foot pad. The mice of experimental groups have been given foods containing 0. 0001%,0. 001%,or 0.01% DDS ,or 0.05% B663 ,or agar-water containing 20 mg RMP per m1 ,respectively. The latter was given a week. Six months after the inoculation,the number of the bacilli in a foot pad of control mice reached 2. 5×10 5,but in the foot pads of ex- perimental mice no bacillus was seen except one of five mice taken RMP. The authors think that BALB/C mice are cheap,easily raised,quickly bred ,and so suitable for studying leprosy.

关 键 词：BALB/C小鼠 麻风菌 实验动物 抗麻风药物 

分 类 号：R978.3[医药卫生—药品] R965.1[医药卫生—药学]