原发性EB病毒感染后特异性T细胞免疫功能的研究进展  

The function of EB virus specific cytotoxic T lymphocytes after primary infection

作　　者：姚瑶[1] 谢正德(综述)[1] 申昆玲(审校)[1] 

机构地区：[1]首都医科大学附属北京儿童医院,100045

出　　处：《国际儿科学杂志》2010年第1期29-32,共4页International Journal of Pediatrics

摘　　要：原发性EB病毒（EBV）感染后机体产生针对裂解期和潜伏期病毒抗原特异性CD8^＋／CD4^＋细胞毒性T细胞（CTL），清除病毒控制EBV感染。EBV原发感染后临床表现多样，造成这一现象的原因尚不明确，其特异性T细胞对控制病毒感染起到关键作用。随访研究发现EBV原发感染后针对裂解期和潜伏期病毒抗原特异性T细胞功能变化不同，同时对EBV特异性T细胞亚群的分析发现，T细胞的迁移活化在EBV感染机制中亦起到重要作用。After primary. EB virus（EBV） infection there are expansions of EBV-speeific CD8^＋/CD4^＋ CTLs responses against lytic peptides and latent peptides in order to control EBV infection. Clinical manifestations of EBV infeetion are diverse.Its pathogenesis is not clear. The surveillance of EBV specific-immunity plays an important role to control viral replication. There are differences between the CTL responses against lytic pepfides and latent peptides. And the migration and activation of EBV specific CTLs with different cell surface molecules play an important role in EBV infection.

关 键 词：爱波斯坦-巴尔病毒感染 T淋巴细胞 细胞毒性 儿童 

分 类 号：R51[医药卫生—内科学]