人巨细胞病毒UL 146基因α趋化因子在巨细胞病毒感染中的作用  

Tire role of human cytomegalovirus UL146 gene-α chemokine in cytomegalovirus infection

作　　者：常淑婷(综述)[1] 毛志芹(审校)[1] 

机构地区：[1]中国医科大学附属盛京医院,沈阳110004

出　　处：《国际儿科学杂志》2010年第1期36-38,共3页International Journal of Pediatrics

摘　　要：人巨细胞病毒（HCMV）在人群中感染非常普遍，对于免疫功能正常的人来说通常是不显性感染或潜伏感染，但胎儿及免疫缺陷患者感染可导致极高的病死率。目前，关于HCMV先天感染的致病机制还不十分清楚。HCMV UL146基因编码α趋化因子同源物，其核苷酸及氨基酸序列的变异和蛋白趋化因子功能区的高度保守提示这个功能区对于HCMV具有重要的生物学意义。Human cytomegalovirus（HCMV） infection is very contain in the population. The form of infection usually presents silent or latent infection in the persons with normal immune function,but it can lead to a high mortality in the fetuses and the patients with immune deficiency.At present,the pathogenesis of the congenital infection by HCMV is not very dear. In the a chemokine homologue encoded by HCMV UL146, the variation of the nucleotide and amino acid sequences and the highly conservative domain suggests that this domain is important for HCMV in biological significance. And the study on the gene polymorphism and the function of its encoding protein will play an important role to reveal the pathogenesis of HCMV.

关 键 词：人巨细胞病毒 UL146基因 趋化因子 

分 类 号：R714.251[医药卫生—妇产科学] R373[医药卫生—临床医学]