Toll样受体在类风湿性关节炎中的作用  

Role of Toll-like receptors in pathogenesis of rheumatoid arthritis

作　　者：时庆康(综述)[1] 陈兰举(审校)[1] 

机构地区：[1]安徽省蚌埠医学院第一附属医院儿科,233004

出　　处：《国际儿科学杂志》2010年第1期42-44,共3页International Journal of Pediatrics

摘　　要：Toll样受体（TLR）是Ⅰ型跨膜受体，在天然免疫和获得性免疫反应中发挥重要作用，近年来被认为是天然免疫系统中的关键受体。TLR通过识别外源性、内源性配体激活天然免疫；同时诱导产生的多种细胞因子是影响初始T细胞分化的关键因素，TLR异常活化可引起Th1、Th2、Th17、Treg细胞功能失衡，从而导致自身免疫性疾病发生。Toll-like receptors（TLRs）, as the family members of type Ⅰ transmembrane reeeptors, play a pivotal role in both innate and adaptive immtme responses. Recently, TLRs are believed to be the critical reeeptors in innate immunity. Innate immunity activated by the recognition of exogenous or endogenous by TLRs induces multiple eytokines that is the key factor to affect differentiation of naive T cells. Abnormal activation of TLRs may cause the functional imbalance Th1,Th2,Th17 and Treg, resulting in the oeeurenee of autoimmtme disease.

关 键 词：TOLL样受体 类风湿性关节炎 信号传导 

分 类 号：R392.11[医药卫生—免疫学] R259.932.2[医药卫生—基础医学]