肺炎支原体体外诱导抗生素耐药及其机制  

Resistance mechanisms to antibiotic in vitro in mycoplasma pnemnoniae

作　　者：史大伟(综述)[1] 辛德莉(审校)[1] 

机构地区：[1]首都医科大学附属北京友谊医院儿科,100050

出　　处：《国际儿科学杂志》2010年第1期82-83,87,共3页International Journal of Pediatrics

基　　金：国家自然科学基金资助项目（30571973）;北京自然科学基金资助项目（7063075）;北京中医药科技管理局资助项目（JJ2005-5）

摘　　要：肺炎支原体（MP）是儿童和青少年社区获得性呼吸道感染的常见病原体，对大环内酯类、四环素类、氨基糖苷类、喹诺酮类等敏感，大环内酯类抗生素是治疗小儿MP感染的首选药物。然而，近年来在实验室诱导出对抗生素耐药的MP，并且体外分离到对大环内酯类抗生素耐药的菌株，结合位点的基因突变是目前的研究热点，也是引起MP耐药的主要机制。对MP耐药性的研究可为临床抗生素的合理选择和应用提供理论指导。Mycoplasma pneumoniae（MP） is a common pathogen found in respiratory tract infections of children and is susceptible to macrolides,tetracyeline,aminogly-ccsidcs, and quinoloincs. Of all these antibiotics,macrolidcs is the frist choice for children. However, in recent years,strains which are resistant to common drugs have been selected in vitro and isolated from patients. Point mutation at antibifics target site of these swains is one of the molecular mechanisms.The study of MP resistance can provide theoretical guidance for rational choice of antibiotics and application.

关 键 词：肺炎 肺炎支原体 耐药 诱导 抗生素 

分 类 号：R978.1[医药卫生—药品] R725.631[医药卫生—药学]