Wnt信号通路与胰岛β细胞增殖的关系  

Wnt signaling and pancreatic β cell proliferation

作　　者：申红梅[1] 刘超[1] 

机构地区：[1]南京医科大学附属第一医院内分泌科,210029

出　　处：《国际内分泌代谢杂志》2010年第1期44-47,共4页International Journal of Endocrinology and Metabolism

摘　　要：Wnt信号转导通路参与调节细胞的增殖、分化、运动及凋亡等，是细胞发育及形态形成所必需。近年来研究发现Wnt信号通路的卷曲蛋白受体在人的胚胎以及成年胰腺的外分泌部和胰岛细胞上都有表达，Wnt信号通路的各种组成成分与胰岛β细胞增殖及胰岛素分泌关系密切。此外，Wnt信号通路的下游靶基因可以调控细胞周期的进程，提示Wnt信号通路在胰岛β细胞增殖、分化过程中发挥重要的作用。Wnt signaling regulates cell proliferation, differentiation, movement, and apoptosis, which is essential in the development and morphogenesis of cells. Recent studies demonstrate the expression of several Wnt ligands and frizzle （serpentine protein） receptor in the embryonic and adult pancreas. The components of Wnt signaling pathway have important relationship with pancreatic β cell proliferation and insulin secretion. Moreover, the downstream target genes of Wnt signaling were found to regulate cell cycle progress,indicating that Wnt signaling plays a significant role in process of pancreatic β proliferation and differentiation.

关 键 词：WNT信号通路 Β-连环蛋白 胰岛Β细胞 增殖 

分 类 号：R33[医药卫生—人体生理学]