妊娠晚期无畸形单胎妊娠母血甲胎蛋白水平的临床意义  

CLINICAL VALUE OF DETECTING MATERNAL SERUM AFP LEVEL IN LATE PREGNANCY OF NORMAL DEVELOPMENT SINGAL FETUS

作　　者：丁依玲[1] 陶光实[1] 朱付凡[1] 李炎升[1] 

机构地区：[1]湖南医科大学第二附属医院妇产科,410003

出　　处：《中国现代医学杂志》1998年第10期5-8,共4页China Journal of Modern Medicine

摘　　要：为了探讨妊娠晚期无畸形单胎妊娠母血AFP水平的临床意义 ,用放射免疫法检测了 10 2例高危及正常妊娠晚期孕妇血清甲胎蛋白。前瞻性观察妊娠结局。结果 :高危和正常妊娠组母血AFP均值分别为 :(12 3 .45±33 .2 4) μg/L ,(99 18± 2 5 .6 8) μg/L ,差异显著 (P <0 .0 1)。以高出正常晚妊孕妇母血AFP 2个标准差 15 0 μg/L为临界值 ;≥ 15 0 μg/L的孕妇羊水胎粪污染、足月小样儿、Ⅲ级胎盘发生率均较母血AFP低于此值的孕妇增高(P <0 .0 5 )。且前者新生儿Apgar评分≤ 7分 ,E/C比值≤ 10的发生率较后者明显增高 (P <0 .0 1)。提示 :妊娠晚期无畸形单胎妊娠母血AFP值可作为间接反应胎盘功能 ,预测妊娠结局的参数之一。Objective: To study the clinical value of maternal serum AFP level in late pregnancy of normal development signle fetus. Methods: Maternal serum AFP of one hundred and two high risk and normal late pregnant women were detected by radioimmunoassay and their gregnant outcome was studied prospectively. Results: Maternal serum AFP in high risk and normal pregnant wormen were (123.45±33.24) ug/L, (99.18±25.68)ug/L respectively (P<0.01). Incidence of meconium stained amniotic fluid, small for date infant, grade Ⅲ placenta, newborn Apgar score equal or lower 7 and E/C ratio equal or lower 10 in the gregnant women whose maternal serum AFP were equal or greater 150ug/L were higher than the incidence of that in those whose serum AFP were lower the number (P<0.05). Conclusion: Maternal serum AFP in late pregnant women of normal development singal fetus probable is a parmeter to reflect indirectly placenta function and predict outcome f pregnancy.

关 键 词：妊娠 放射免疫检测 AFP 胎盘功能 

分 类 号：R714.12[医药卫生—妇产科学]