心肌缺血模型大鼠气虚证相关信息的评价  

Evaluation of relevant informations in myocardial ischemic rats with qi-deficiency syndrome

作　　者：仇琪[1] 王勇[1] 李春[1] 陈婵[1] 郭淑贞[1] 王伟[1] 

机构地区：[1]北京中医药大学,北京100029

出　　处：《中华中医药杂志》2010年第2期210-213,I0001,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家重点基础研究发展计划(973计划)(No.2003CB517105);国家科技重大专项课题(No.2009ZX09502)~~

摘　　要：目的:探究心肌缺血模型大鼠的证候属性,对模型大鼠气虚证相关信息进行客观评价。方法:采用左冠状动脉结扎法复制大鼠心肌缺血模型,术后多个时间点,动态观察大鼠宏观体征,计算安静状态下呼吸频率、应激后呼吸频率和游泳力竭时间,采用超声心动法,评价术后各时间点大鼠心功能。结果:模型组大鼠术后7-60d,安静状态下呼吸频率下降,应激后呼吸频率增加;心功能明显下降;术后8-29d,模型组大鼠游泳力竭时间明显缩短。结论:左冠状动脉结扎法造成的心肌缺血大鼠在术后7-60d内同时具备血瘀证和气虚证相关指证。Objective： To investigate the syndrome property of myocardial Ischemic, and evaluate the relevant informations of qi-deficiency. Methods： SD rats were subjected to either proximal LAD ligation or sham operation. The respiratory rate in both resting state and post-stress were counted. 20 rats （10 in each group） were subjected to forced swimming test （FST） to measure the exhaustive swimming time in every time point Echocardiography was used to evaluate the cardiac function in rats at each time point. Results： Compared with sham operation group, the respiratory rate in the resting state was slower, but faster under post-stress, the exhaustive swimming time was shorter, and the cardiac function of rats was significant decreasing in model group during the period from 7th day to 60th day after operation. The exhaustive swimming time was much shorter, and the relevant information of blood stasis was abnormal in the mode/group during the period from 7th day to 28th day after operation, when compared with the sham group. Conclusion： Myocardial ischemic rats induced by LAD ligation had both qi-deficiency and blood stasis indications, can be diagnosed as the syndrome of qi-deficiency and blood stasis during the period from 7th day to 28th day after operation. The model rats only had the qi-deficiency indications during the period from 45th day to 60th day after operation, so can be diagnosed as the qi-deficiency syndrome.

关 键 词：心肌缺血 气虚证 大鼠 动物模型 

分 类 号：R259[医药卫生—中西医结合]