律复康胶囊对乌头碱诱发大鼠心律失常的影响  

Study of Lvfukang Capsules on experimental arrhythmia induced by aconitine in rats

作　　者：韩丽华[1] 王振涛[1] 陈舒茵[2] 申洪超[2] 黎瑞汝[2] 梁生旺[2] 张会超[1] 

机构地区：[1]河南省中医院心内科,郑州450011 [2]广东药学院中药学院,广州510006

出　　处：《中华中医药杂志》2010年第2期299-300,共2页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：河南省科技创新人才计划项目(No.0621002700)~~

摘　　要：目的:通过观察律复康胶囊对乌头碱诱发大鼠心律失常模型的对抗作用,为临床用药提供依据。方法:取实验大鼠50只,均分为模型对照组(等容量蒸馏水)、阳性对照组(稳心颗粒4.860g生药/kg)、律复康胶囊小(1.787g生药/kg)、中(3.574g生药/kg)、大剂量(7.148g生药/kg)组,各组大鼠按剂量给药3d,末次药后30min,用乌头碱诱发大鼠心律失常模型,观察记录室性早搏(ventricular premature beat,VP),以及室性心动过速(ventricular tachycardia,VT)出现的时间。结果:律复康胶囊各剂量组均能推迟室性早搏、室性心动过速的出现时间,与模型对照组比较有显著性差异(P<0.05或P<0.01)。结论:律复康胶囊能够明显推迟乌头碱诱发的大鼠室性早搏,室性心动过速出现的时间,说明律复康胶囊对乌头碱诱发的心律失常有一定对抗作用。Objective： To observe the anti- arrhythmic effects of Lvfukang Capsules on the experimental arrhythmic models induced by aconitine in rats, and provid accordance for clinical medication. Methods： 50 rats were divided into model control group, positive control group, high, middle and low dosage groups of Lvfukang Capsules, respectively. All the dosage groups were treated with successive medication 3 days, arrhythmic models induced by aconitine for 30minutes after the last dosage. To observe and record the time of ventricular premature beat （VP） and ventricular fibrillation （VF）. Results： All the dosage groups of Lvfukang Capsules significantly delayed the time of ventricular premature beat （VP） and ventricular tachycardia （VT） of arrhythmic models of rats （P〈 0.05 orP〈 0.01）. Conclusion： Lvfukang Capsules delayed the time of VP and VT of the experimental arrhythmic models induced by aconitine, It had antiarrhythmic effects on the experimental arrhythmic models induced by aconitine.

关 键 词：律复康 心律失常 乌头碱 大鼠 

分 类 号：R285.5[医药卫生—中药学]