胃炎饮对实验性胆汁反流性胃炎大鼠血浆胃动素含量的影响  

Effect of Weiyanyin on content of MOT in blood plasma of experiment bile reflux gastritis rats

作　　者：杨牧祥[1] 于文涛[1] 王长垠[2] 胡金宽[1] 李俊仙[1] 

机构地区：[1]河北医科大学中医学院,石家庄050091 [2]邯郸市中医院,邯郸056001

出　　处：《中华中医药杂志》2010年第2期302-303,共2页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：河北省中医药管理局科学研究计划项目(No.2007016)~~

摘　　要：目的探讨胃炎饮对实验性胆汁反流性胃炎大鼠血浆胃动素(MOT)含量的影响。方法:采用自制反流液灌胃建立实验性胆汁反流性胃炎大鼠模型,以吗叮啉为对照,观察胃炎饮对实验性胆汁反流性胃炎大鼠血浆MOT含量的影响。结果:模型组大鼠血浆MOT水平明显下降;与模型组比较,各治疗组均可明显升高MOT含量(P<0.05或P<0.01),胃炎饮高、低剂量组MOT含量明显高于吗叮啉组(P<0.05)。结论:胃炎饮可提高血浆MOT含量,促进消化间期胃排空和反流液的清除。Objective： To observe the effect of Weiyanyin on Motilin （MOT） in blood plasma of experiment bile reflux gastritis rats. Methods： To make the model of experiment bile reflux gastritis by drinking reflux liquid, compared with Domperidone.The effect of Weiyanyin on Pathological histology and MOT in blood plasma of bile reflux gastritis rats was observed. Results： The mucosal of rats in model group was damaged, amotic, and a lot of inflammatory cell could be seen, glandular organ hyperplasy and intestinal metaplasia in most of rats; At the same time the content of the MOT was decreased; Compared with model group, Weiyanyin could improve pathological histology of experiment bile reflux gastritis rats, and increase the content of MOT （ P〈0.01 ） . The content of MOT in high, low dosage group Compared with the control group was significant （ P〈0.05 ） . Conclusion： Weiyanyin could increase the content of MOT, promote interdigestive phase gastric emptying and remove reflux liquid.

关 键 词：胃炎饮 实验性胆汁反流性胃炎 胃动素 

分 类 号：R285.5[医药卫生—中药学]