一种新的四肽(TFA-Gly-Pro-Thr-Ala-OH)合成工艺  

Synthesis of TFA-Gly-Pro-Thr-Ala-OH

作　　者：吴修艮[1] 丁德平[1] 聂丽云[1] 高瑞银[1] 

机构地区：[1]江苏吉贝尔药业有限公司,江西镇江212009

出　　处：《齐鲁药事》2010年第1期47-48,共2页qilu pharmaceutical affairs

摘　　要：目的确定一种新的四肽(TFA-Gly-Pro-Thr-Ala-OH)合成工艺。方法以Boc-Gly-OSu、Boc-Thr-OSu、丙氨酸和脯氨酸为原料,选择适当的反应条件,得Boc-Gly-Pro-Thr-Ala-OH,再通过反应生成更稳定的目标产物。结果收率较高,质量稳定。结论本合成的新的四肽在收率、有关物质等方面都符合要求。OBJECTIVE To establish a new synthetic route of TFA--Gly--Pro--Thr--Ala--OH. METHODS Selected appropriate reaction conditions,with Boc--Gly--OSu,Boc--Thr--OSu,alanine and proline as the raw materials,Boc--Gly--Pro --Thr--Ala--OH was get,then the more stable target product was made through the reactions. RESULTS The method has a high yield and stable quality. CONCLUSION The yield and related substance of the new tetrapeptide obtained by this route were met with the requirements.

关 键 词：TFA—Gly—Pro-Thr—Ala—OH 抗肿瘤 化合物 合成 

分 类 号：TQ464.7[化学工程—制药化工]