布托啡诺联合舒芬太尼用于腹部手术术后皮下镇痛的临床观察  

The clinical observation of butorphanol combined sufentanil for postoperative analgesia after subcutaneous

作　　者：陈勇[1] 董理[1] 

机构地区：[1]成都铁路中心医院麻醉科,成都市610081

出　　处：《临床合理用药杂志》2010年第4期40-41,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察布托啡诺联合舒芬太尼用于腹部手术术后皮下镇痛效果和不良反应发生情况。方法40例择期腹部手术的患者,随机分为Ⅰ、Ⅱ2组。2组术毕前静脉缓注布托啡诺0.75mg,手术结束后于患者三角肌处埋针置管连接镇痛泵:Ⅰ组给予布托啡诺4mg+舒芬太尼50μg+2%利多卡因200mg,Ⅱ组给予芬太尼1.0mg+2%利多卡因200mg;每组均用生理盐水稀释至200ml,背景剂量3ml/h,患者自控镇痛(PCA)2ml,锁定时间为15min。分别记录术后4、12、24和48h的平均动脉压(MAP)、心率(HR)、呼吸频率(RR)、氧饱和度(SpO2)、患者平静时的视觉模拟(VAS)疼痛评分,统计不良反应,并在镇痛结束后统计患者对镇痛治疗的总体满意度。结果2组患者术后各时间点MAP、HR及SpO2、VAS评分不良反应发生率和患者满意度差异均无统计学意义(P>0.05)。结论布托啡诺联合舒芬太尼用于腹部手术术后皮下镇痛效果是满意的,是一种安全有效的术后镇痛的方法。Objective To observe the effect of butorphanol combined sufentanil for postoperative analgesia after subcutaneous and adverse reactions. Methods 40 patients undergoing elective abdominal surgery patients were randomly divided into Ⅰ group and Ⅱ group. Patients were slow intravenous injection butorphanol 0.75mg before surgery completion,after the end of surgery in patients with deltoid buried needle catheter connected analgesia pump：the patients in Ⅰ group were gaven butorphanol 4mg ＋ sufentanil 50μg ＋ 2% lidocaine 200mg, Ⅱ group were gaven fentanyl 1.0mg ＋ 2% lidocaine 200mg ; Each group with 0.9% normal saline diluted to 200ml,the background dose was 3ml/h,PCA 2ml,lockout time wasl 5rain. When after surgery 4,12,24 and 48 hours recording the mean arterial pressure（MAP） ,heart rate（HR） ,respiratory rate（RR） ,pulse saturation （SpO2 ） , the visual analogue（VAS） pain score when calm, counted the adverse reactions and the overall patient satisfaction with pain treatment after the end of analgesia. Results The MAP, HR, SpO2 and post-operative VAS score of patients at different time points after surgery was no significant difference（ P 〉 0. 05 ）. Conclusion Butorphanol combined sufentanil for postoperative abdominal subcutaneous analgesic effect is satisfactory, it＇s a safe and effective method of postoperative analgesia.

关 键 词：布托啡诺 舒芬太尼 腹部手术 皮下自控镇痛 

分 类 号：R614[医药卫生—麻醉学]