急性冠状动脉综合征患者血浆氧化脂蛋白(a)水平  

Plasma oxidized lipoprotein(a) levels in patients with acute coronary artery disease

作　　者：韩爱忠[1,2] 汪俊军[2] 孟扬[1,2] 张春妮[2] 李克[2] 

机构地区：[1]南京师范大学生命科学学院江苏省分子医学生物技术重点实验室,南京210046 [2]南京军区南京总医院检验科,南京210002

出　　处：《临床检验杂志》2010年第1期24-26,共3页Chinese Journal of Clinical Laboratory Science

基　　金：国家自然科学基金资助项目(30872411和30471649)

摘　　要：目的探讨急性冠状动脉综合征(ACS)患者血浆氧化脂蛋白(a)[ox-Lp(a)]水平的变化及机制。方法分别检测96例ACS、89例非ACS患者和100例健康人血浆ox-Lp(a)水平,冠状动脉造影确认冠状动脉病变程度。结果ACS组和非ACS组ox-Lp(a)水平均高于对照组,且ACS组ox-Lp(a)水平显著高于非ACS组。ACS组ox-Lp(a)/Lp(a)比值高于非ACS组和健康对照组,后两者中该比值无显著差别。ACS患者中ox-Lp(a)水平与冠状动脉病变程度相关(r=0.370,P=0.000),非ACS组中两者不相关(r=0.051,P=0.634)。多因素分析显示,ox-Lp(a)、TG水平及年龄解释ACS患者15.1%的病变程度。结论高ox-Lp(a)水平与ACS的发生、病变程度有关,有益于鉴别ACS。Objective To investigate the association of increased oxidized lipoprotein（a） [ ox-Lp（a） ] levels with the severity of acute coronary syndromes （ACS） and relevant possible mechanisms. Methods Ox-Lp （a） levels were measured in 96 ACS patients, 89 non-ACS patients, and 100 healthy subjects. The extent of coronary artery disease （CAD） was determined by coronary angiography. Results Ox-Lp（a） levels significantly increased in ACS or non-ACS patients, compared with those in control. ACS patients had higher ox-Lp（a） levels than non-ACS patients. The ratio of ox-Lp（a） to Lp（a） in ACS was higher than that in either non-ACS or control, whereas the ratio was comparable between the non-ACS and control. Ox-Lp （a） levels were found to be associated with a graded increase with the severity of CAD in the ACS （ r = 0. 370, P =0. 001 ）, yet not in the non-ACS （ r = 0.051, P = 0.634）. Multiple linear regression analysis showed that ox-Lp（ a）, triglyceride, and age accounted for 15.1% of the variation in the severity of CAD in ACS patients. Conclusions Elevated ox-Lp（a） levels are associated with the presence and severity of ACS, and testing ox-Lp （a） may be useful in identifying ACS patients.

关 键 词：脂蛋白 氧化 动脉粥样硬化 急性冠状动脉综合征 冠心病 

分 类 号：R446.1[医药卫生—诊断学]